Restoration and targeting of aberrant neurotransmitters in Parkinson's disease therapeutics

D Yadav, P Kumar - Neurochemistry international, 2022 - Elsevier
Neurotransmitters are considered as a fundamental regulator in the process of neuronal
growth, differentiation and survival. Parkinson's Disease (PD) occurs due to extensive …

Review of the cytology and connections of the lateral habenula, an avatar of adaptive behaving

DS Zahm, DH Root - Pharmacology Biochemistry and Behavior, 2017 - Elsevier
The cytology and connections of the lateral habenula (LHb) are reviewed. The habenula is
first introduced, after which the cytology of the LHb is discussed mainly with reference to cell …

The α1 and γ2 subunit-containing GABAA receptor-mediated inhibitory transmission in the anteroventral bed nucleus of stria terminalis is involved in the regulation of …

R Li, Y Wang, Y Yang, Z Wu, L Wang, G Tang, J Yang… - …, 2023 - Elsevier
The anteroventral bed nucleus of the stria terminalis (avBNST) is widely acknowledged as a
key brain structure that regulates negative emotional states, such as anxiety. At present, it is …

Anxiety during alcohol withdrawal involves 5-HT2C receptors and M-channels in the lateral habenula

R Fu, Q Mei, N Shiwalkar, W Zuo, H Zhang, D Gregor… - …, 2020 - Elsevier
Anxiety disorders often co-occur with alcohol use disorders, but the mechanisms underlying
this comorbidity remain elusive. Previously, we reported that rats withdrawn from chronic …

[HTML][HTML] Altered GABAergic signaling in brain disease at various stages of life

YS Kim, BE Yoon - Experimental neurobiology, 2017 - ncbi.nlm.nih.gov
In the healthy brain, gamma-aminobutyric acid (GABA) is regulated by neurons and glia.
This begs the question: what happens in the malfunctioning brain? There are many reasons …

The avBNSTGABA–VTA and avBNSTGABA–DRN pathways are respectively involved in the regulation of anxiety-like behaviors in parkinsonian rats

R Li, G Tang, J Yang, S Gao, Y Wang, X Wu… - Neurochemistry …, 2024 - Elsevier
The anteroventral bed nucleus of stria terminalis (avBNST) is a key brain region which
involves negative emotional states, such as anxiety. The most neurons in the avBNST are …

[HTML][HTML] Mood disturbances in Parkinson's disease: From prodromal origins to application of animal models

S Hayley, F Vahid-Ansari, H Sun, PR Albert - Neurobiology of Disease, 2023 - Elsevier
Parkinson's disease (PD) is a complex illness with a constellation of environmental insults
and genetic vulnerabilities being implicated. Strikingly, many studies only focus on the …

Neuropsychiatric disorders in Parkinson's disease: what do we know about the role of dopaminergic and non-dopaminergic systems?

K Dujardin, V Sgambato - Frontiers in neuroscience, 2020 - frontiersin.org
Besides the hallmark motor symptoms (rest tremor, hypokinesia, rigidity, and postural
instability), patients with Parkinson's disease (PD) have non-motor symptoms, namely …

Inhibition within the lateral habenula—Implications for affective disorders

JF Webster, S Lecca, C Wozny - Frontiers in Behavioral Neuroscience, 2021 - frontiersin.org
The lateral habenula (LHb) is a key brain region implicated in the pathology of major
depressive disorder (MDD). Specifically, excitatory LHb neurons are known to be …

Downregulation of astroglial glutamate transporter GLT-1 in the lateral habenula is associated with depressive-like behaviors in a rat model of Parkinson's disease

S Lyu, Y Guo, L Zhang, G Tang, R Li, J Yang, S Gao… - …, 2021 - Elsevier
Recent studies show that neuron-glial communication plays an important role in
neurological diseases. Particularly, dysfunction of astroglial glutamate transporter GLT-1 has …