Spatiotemporal gene expression programmes are orchestrated by transcriptional
enhancers, which are key regulatory DNA elements that engage in physical contacts with …

Proper expression of genes requires communication with their regulatory elements that can
be located elsewhere along the chromosome. The physics of chromatin fibers imposes a …

Enhancers are important regulatory elements that can control gene activity across vast
genetic distances. However, the underlying nature of this regulation remains obscured …

The genome is partitioned into topologically associated domains and genomic
compartments with shared chromatin valence. This architecture is constrained by the DNA …

BACKGROUND The eukaryotic genome is hierarchically organized in the cell nucleus into
DNA loops, chromatin domains, compartments, and, ultimately, chromosomes. Many of the …

SARS-CoV-2 infects less than 1% of cells in the human body, yet it can cause severe
damage in a variety of organs. Thus, deciphering the non-cell-autonomous effects of SARS …

Mammalian genomes are folded into spatial domains, which regulate gene expression by
modulating enhancer-promoter contacts. Here, we review recent studies on the structure …

Super-enhancers are compound regulatory elements that control expression of key cell
identity genes. They recruit high levels of tissue-specific transcription factors and co …

Olfactory receptor (OR) choice provides an extreme example of allelic competition for
transcriptional dominance, where every olfactory neuron stably transcribes one of …

The biological olfactory system is the sensory system responsible for the detection of the
chemical composition of the environment. Several attempts to mimic biological olfactory …