This review of the mechanism of pulmonary hypertension is focused on pulmonary arterial
hypertension, a disorder that can be idiopathic or can occur in association with other …

Pulmonary arterial hypertension (PAH) is a complex disease that causes significant
morbidity and mortality and is clinically characterized by an increase in pulmonary vascular …

Primary pulmonary hypertension is a fatal disease causing progressive right heart failure
within 3 years after diagnosis. We describe a new concept for treatment of the disease using …

A greater understanding of the epidemiology, pathogenesis, and pathophysiology of
pulmonary artery hypertension (PAH) has led to significant advances, but the disease …

Background—Vasoactive intestinal peptide (VIP), a pulmonary vasodilator and inhibitor of
vascular smooth muscle proliferation, has been reported absent in pulmonary arteries from …

Pulmonary arterial hypertension (PAH) is a progressive and devastating disease
characterized by pulmonary artery vasoconstriction and vascular remodeling leading to …

Pulmonary hypertension (PH) is a debilitating disease with a poor prognosis. Therapeutic
options remain limited despite the introduction of prostacyclin analogues, endothelin …

Pulmonary hypertension (PH), defined as a mean pulmonary arterial (PA) pressure of> 25
mmHg at rest or> 30 mmHg during exercise, is characterized by a progressive and …

There is mounting evidence that pulmonary arterial hypertension (PAH), asthma and chronic
obstructive pulmonary disease (COPD) share important pathological features, including …

Human heart disease is a major cause of death and disability. A variety of animal models of
cardiac disease have been developed to better understand the etiology, cellular and …