Acetylation of lysine residues is a post-translational modification with broad relevance to
cellular signalling and disease biology. Enzymes that 'write'(histone acetyltransferases …

NAD+-dependent Class III histone deacetylase SIRT1 is a multiple function protein critically
involved in stress responses, cellular metabolism and aging through deacetylating a variety …

The yeast Sir2 protein mediates chromatin silencing through an intrinsic NAD‐dependent
histone deacetylase activity. Sir2 is a conserved protein and was recently shown to regulate …

Histone proteins are subject to modifications, such as acetylation, methylation,
phosphorylation, ubiquitination, glycosylation, and ADP ribosylation, some of which are …

PML is a component of a multiprotein complex, termed nuclear bodies, and the PML protein
was originally discovered in patients suffering from acute promyelocytic leukaemia (APL) …

Nanog and Oct4 are essential transcription factors that regulate self-renewal and
pluripotency of ES cells. However, the mechanisms by which Nanog and Oct4 modulate ES …

The Wnt-responsive transcription factor LEF1 can activate transcription in association with β-
catenin and repress transcription in association with Groucho. In search of additional …

The identification of recurrent somatic mutations in genes encoding epigenetic enzymes has
provided a strong rationale for the development of compounds that target the epigenome for …

Acetylation and deacetylation of chromatin histone protein by histone deacetylase (HDAC)
alters chromatin structure and dynamically affects transcriptional regulation. Many lines of …

ND10, PML bodies or PODs have become the defining nuclear structure for a highly
complex protein complement involved in cell activities such as aging, apoptosis, the cell …