Squaraine dyes: molecular design for different applications and remaining challenges

K Ilina, WM MacCuaig, M Laramie… - Bioconjugate …, 2019 - ACS Publications
Squaraine dyes are a class of organic dyes with strong and narrow absorption bands in the
near-infrared. Despite high molar absorptivities and fluorescence quantum yields, these …

Biosensing platform for the detection of biomarkers for ALI/ARDS in Bronchoalveolar lavage fluid of LPS mice model

NK Alekhmimi, D Cialla-May, Q Ramadan, S Eissa… - Biosensors, 2023 - mdpi.com
Acute respiratory distress syndrome (ARDS) is a worldwide health concern. The
pathophysiological features of ALI/ARDS include a pulmonary immunological response. The …

Human neutrophil elastase activated fluorescent probe for pulmonary diseases based on fluorescence resonance energy transfer using CdSe/ZnS quantum dots

SY Liu, AM Yan, WYZ Guo, YY Fang, QJ Dong, RR Li… - ACS …, 2020 - ACS Publications
There is an increasing demand for effective noninvasive diagnosis against common
pulmonary diseases, which are rising sharply due to the serious air pollution. Human …

A bovine serum albumin and squaraine dye assembly fluorescent probe for pepsin detection

Q Jiang, Z Chen, Y Huang, Q Gao, C Luo, M Mehdi… - Microchemical …, 2023 - Elsevier
Gastroesophageal reflux disease (GERD) is a highly prevalent condition. Screening for
GERD remains a great challenge due to the non-specific nature of the symptoms. Now …

Oligo (ethylene glycol)-functionalized squaraine fluorophore as a near-infrared-fluorescent probe for the in vivo detection of diagnostic enzymes

B Wu, Y Lin, B Li, C Zhan, F Zeng, S Wu - Analytical chemistry, 2018 - ACS Publications
Squaraine dyes have excellent photostability with intensive absorption and strong
fluorescence in the near-infrared (NIR) region. However, they display a strong tendency to …

Coumarin-based turn-on fluorescence probe with a large Stokes shift for detection of endogenous neutrophil elastase in live cells and zebrafish

Q Sun, X Li, Y Guo, Y Qiu, X Luo, G Liu… - Spectrochimica Acta Part A …, 2022 - Elsevier
Neutrophil elastase (NE), a serine proteinase, is a significant biomarker which is closely
related to the progress of diseases. However, only few probes have been reported for …

[HTML][HTML] Design and Synthesis of Novel Squaraine-Based Fluorescent Probe for Far-Red Detection of Chymotrypsin Enzyme

S Gupta, P Balyan, SK Mavileti, SS Pandey, T Kato - Molecules, 2024 - mdpi.com
Chymotrypsin, a crucial enzyme in human digestion, catalyzes the breakdown of milk
proteins, underscoring its significance in both health diagnostics and dairy quality …

Intermediate diradical character and thermal cis–trans isomerization of near-infrared absorbing thionated squaraine dyes

T Oka, T Maeda, D Sakamaki, N Suzuki… - Organic Chemistry …, 2025 - pubs.rsc.org
We synthesized squaraine dyes incorporating 4-membered thionated oxocarbon and
chalcogenopyrylium moieties, which displayed intermediate diradical character as …

Dual emissive bispyrene peptide probes for highly sensitive measurements of trypsin activity and evaluation of trypsin inhibitors

D Sato, T Kondo, T Kato - Bioorganic & Medicinal Chemistry, 2018 - Elsevier
Peptide substrates were double labeled with pyrenes to prepare fluorescent probes for
highly sensitive detection of protease activity and evaluation of protease inhibitors using …

Extended conjugation in stilbenoid squaraines

H Meier - Zeitschrift für Naturforschung B, 2019 - degruyter.com
Squaraines, two-fold condensation products in 1, 3-position of squaric acid, represent dyes
or pigments of high actuality. After their first boom in electrophotography diverse applications …