Molecular testing for thyroid nodules: Where are we now?

C Ferraz - Reviews in Endocrine and Metabolic Disorders, 2024 - Springer
Approximately 25% of the fine needle aspiration samples (FNAB) of thyroid nodules are
classified as “indeterminate samples”, that means, Bethesda III and IV categories. Until the …

Preoperative detection of malignancy in fine-needle aspiration cytology (FNAC) smears with indeterminate cytology (Bethesda III, IV) by a combined molecular …

S Titov, PS Demenkov, SA Lukyanov… - Journal of Clinical …, 2020 - jcp.bmj.com
Aims Analysis of molecular markers in addition to cytological analysis of fine-needle
aspiration (FNA) samples is a promising way to improve the preoperative diagnosis of …

Performance of a dual-component molecular assay in cytologically indeterminate thyroid nodules

M Sponziello, C Brunelli, A Verrienti, G Grani, V Pecce… - Endocrine, 2020 - Springer
Purpose Deciding whether patients with a cytologically indeterminate thyroid nodule should
be referred for surgery or for active surveillance is an important challenge for clinicians. The …

Use of long non-coding RNAs for the molecular diagnosis of papillary thyroid cancer

D Kim, J Yu, J Kim, Y Hwang, JK Kim, CR Ku… - Frontiers in …, 2022 - frontiersin.org
Objective Improved molecular testing for common somatic mutations and the identification of
mRNA and microRNA expression classifiers are promising approaches for the diagnosis of …

Combining the American Thyroid Association's ultrasound classification with cytological subcategorization improves the assessment of malignancy risk in …

AM Larcher de Almeida, RLC Delfim, APA Vidal… - Thyroid, 2021 - liebertpub.com
Background: The risk of malignancy (RoM) of indeterminate thyroid nodules (ITNs) shows a
high variability in interinstitutional cohorts. The RoM is partially associated with the …

[HTML][HTML] Could a novel category of molecular testing be emerging?

C Ferraz, LS Ward - Chinese Clinical Oncology, 2023 - cco.amegroups.org
Thyroid nodules have been increasingly common in our daily lives and the combination of
thyroid ultrasonography and fine needle aspiration biopsy (FNAB) remains the gold …

Are the anatomical, clinical, and ultrasound characteristics of thyroid nodules with Bethesda III or IV cytology and ACR TI-RADS 3, 4, or 5 able to refine the indications …

GC Penna, CT Costa, MC Pires… - Archives of Endocrinology …, 2021 - SciELO Brasil
Objective: To analyze the association of clinical, anatomical, and ultrasound (US)
characteristics of malignancies in Bethesda III or IV (III-B or IV-B) thyroid nodules. Subjects …

Testing of mutations on thyroid nodules with indeterminate cytology: A prospective study of 112 patients in Argentina

N Tolaba, Y Spedalletti, P Bazzoni, M Galindez… - … , Diabetes y Nutrición …, 2022 - Elsevier
Background The study of genetic mutations in thyroid nodules makes it possible to improve
the preoperative diagnosis of and reduce unnecessary surgeries on benign nodules. In this …

Testeo de mutaciones en nódulos tiroideos con citología indeterminada: estudio prospectivo de 112 pacientes en Argentina

N Tolaba, Y Spedaletti, P Bazzoni, M Galindez… - … , Diabetes y Nutrición, 2022 - Elsevier
Antecedentes El estudio de mutaciones presentes en nódulos tiroideos permite mejorar el
diagnóstico preoperatorio y reducir la realización de cirugías innecesarias de nódulos …

Critical analysis of molecular tests in indeterminate thyroid nodules

DLS Danilovic, S Marui - Archives of Endocrinology and Metabolism, 2018 - SciELO Brasil
The prevalence of thyroid nodules has increased in the last decades, mostly due to the
widespread use of cervical imaging for investigation of pathologies not related to thyroid …