In order to understand the functioning of organisms on the molecular level, we need to know
which genes are expressed, when and where in the organism, and to which extent. The …

Waddington's epigenetic landscape is probably the most famous and most powerful
metaphor in developmental biology. Cells, represented by balls, roll downhill through a …

It is becoming increasingly clear that bistability (or, more generally, multistability) is an
important recurring theme in cell signaling. Bistability may be of particular relevance to …

Intuitively, good and bad outcomes affect our emotional state, but whether the emotional
state feeds back onto the perception of outcomes remains unknown. Here, we use …

In the field of biological regulation, models dictated by expreimental work are usually
complex networks comprising intertwined feedback loops. In this paper the biological roles …

Abstract Background Late-onset Alzheimer's disease (AD) is a complex multifactorial
affliction, the pathogenesis of which is thought to involve gene-environment interactions that …

In summer, the honeybee (Apis mellifera) worker population consists of two temporal castes,
a hive bee group performing a multitude of tasks including nursing inside the nest, and a …

A biological introduction serves to remind us that differentiation is an epigenetic process,
that multistationarity can account for epigenetic differences, including those involved in cell …

MOTIVATION: A large number of molecular mechanisms at the basis of gene regulation
have been described during the last few decades. It is now becoming possible to address …

We state precisely and demonstrate two conjectures of R. Thomas following which (a) the
existence of a positive circuit in the oriented interaction graph of a differential system is a …