Recent investigations have provided an increasingly complete picture of the genetic
landscape of chronic lymphocytic leukaemia (CLL). These analyses revealed that the CLL …

T cells are the key mediators in cell-mediated immunity. Their development and maturation
involve a complex variety of interactions with nonlymphoid cell products and receptors …

Highlights•Ikaros family proteins are essential for lymphocyte development and
function.•Ikaros family deficiency in man leads to B cell deficiency, leukemia development …

Notch signaling has pleiotropic context‐specific functions that have essential roles in many
processes, including embryonic development and maintenance and homeostasis of adult …

A subgroup of pediatric acute T-lymphoblastic leukemia (T-ALL) was characterized by a
gene expression profile comparable to that of early T-cell precursors (ETPs) with a highly …

T cell differentiation requires Notch1 signaling. In the present study, we show that an
enhancer upstream of Notch1 active in double-negative (DN) mouse thymocytes is …

The Ikaros family of DNA-binding proteins are critical regulators of lymphocyte
differentiation. In multipotent, hematopoietic progenitors, Ikaros supports transcriptional …

Notch receptors participate in a conserved pathway in which ligands expressed on
neighboring cells trigger a series of proteolytic cleavages that allow the intracellular portion …

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy largely caused by
aberrant activation of the TAL1/SCL, LMO1/2, and NOTCH1 oncogenes. Approximately 30 …

Ewing's sarcoma is a highly malignant bone tumor found in children and adolescents, and
the origin of this malignancy is not well understood. Here, we introduced a Ewing's sarcoma …