Rho-class small GTPases are implicated in basic cellular processes at nearly all brain
developmental steps, from neurogenesis and migration to axon guidance and synaptic …

The Rho family GTPases are small G proteins that act as molecular switches shuttling
between active and inactive forms. Rho GTPases are regulated by two classes of regulatory …

Gephyrin is the main scaffolding protein at inhibitory postsynaptic sites, and its clusters are
the signaling hubs where several molecular pathways converge. Post-translational …

The fidelity of inhibitory neurotransmission is dependent on the accumulation of γ-
aminobutyric acid type A receptors (GABA A Rs) at the appropriate synaptic sites. Synaptic …

Posttranslational addition of a small ubiquitin-like modifier (SUMO) moiety (SUMOylation)
has been implicated in pathologies such as brain ischemia, diabetic peripheral neuropathy …

GABAergic interneuron diversity is a key feature in the brain that helps to create different
brain activity patterns and behavioral states. Cell type classification schemes—based on …

Triptolide is an epoxidized diterpene lactone isolated from Tripterygium wilfordii. Studies
have shown that triptolide exerts organ‐protective effects. However, it remains unknown …

Rho GTPases play essential roles in various life activities. Rho GTPase-activating protein
(RhoGAP) and Rho guanine nucleotide exchange factor (RhoGEF) are the main regulators …

Mastication stimuli are known to relieve senile dementia in human and animal studies.
However, few studies have focused on its effect on weaning-stage animals and the …

GABAergic inhibitory neurotransmission contributes to diverse aspects of brain development
and adult plasticity, including the expression of complex cognitive processes. This is …