Post-transcriptional regulatory functions of mammalian pumilio proteins
AC Goldstrohm, TMT Hall, KM McKenney - TRENDS in Genetics, 2018 - cell.com
Mammalian Pumilio proteins, PUM1 and PUM2, are members of the PUF family of sequence-
specific RNA-binding proteins. In this review, we explore their mechanisms, regulatory …
specific RNA-binding proteins. In this review, we explore their mechanisms, regulatory …
Mapping the route from naive pluripotency to lineage specification
T Kalkan, A Smith - … Transactions of the Royal Society B …, 2014 - royalsocietypublishing.org
In the mouse blastocyst, epiblast cells are newly formed shortly before implantation. They
possess a unique developmental plasticity, termed naive pluripotency. For development to …
possess a unique developmental plasticity, termed naive pluripotency. For development to …
Noncoding RNA NORAD regulates genomic stability by sequestering PUMILIO proteins
Long noncoding RNAs (lncRNAs) have emerged as regulators of diverse biological
processes. Here, we describe the initial functional analysis of a poorly characterized human …
processes. Here, we describe the initial functional analysis of a poorly characterized human …
[HTML][HTML] Single-cell quantification of ribosome occupancy in early mouse development
Translation regulation is critical for early mammalian embryonic development. However,
previous studies had been restricted to bulk measurements, precluding precise …
previous studies had been restricted to bulk measurements, precluding precise …
A mild PUM1 mutation is associated with adult-onset ataxia, whereas haploinsufficiency causes developmental delay and seizures
Certain mutations can cause proteins to accumulate in neurons, leading to
neurodegeneration. We recently showed, however, that upregulation of a wild-type protein …
neurodegeneration. We recently showed, however, that upregulation of a wild-type protein …
Genetic exploration of the exit from self-renewal using haploid embryonic stem cells
Self-renewal circuitry in embryonic stem cells (ESCs) is increasingly defined. How the robust
pluripotency program is dissolved to enable fate transition is less appreciated. Here we …
pluripotency program is dissolved to enable fate transition is less appreciated. Here we …
Pumilio1 haploinsufficiency leads to SCA1-like neurodegeneration by increasing wild-type Ataxin1 levels
Summary Spinocerebellar ataxia type 1 (SCA1) is a paradigmatic neurodegenerative
proteinopathy, in which a mutant protein (in this case, ATAXIN1) accumulates in neurons …
proteinopathy, in which a mutant protein (in this case, ATAXIN1) accumulates in neurons …
Human Pumilio proteins recruit multiple deadenylases to efficiently repress messenger RNAs
J Van Etten, TL Schagat, J Hrit, CA Weidmann… - Journal of Biological …, 2012 - ASBMB
PUF proteins are a conserved family of eukaryotic RNA-binding proteins that regulate
specific mRNAs: they control many processes including stem cell proliferation, fertility, and …
specific mRNAs: they control many processes including stem cell proliferation, fertility, and …
Post-transcriptional regulation of mouse neurogenesis by Pumilio proteins
Despite extensive studies on mammalian neurogenesis, its post-transcriptional regulation
remains under-explored. Here we report that neural-specific inactivation of two murine post …
remains under-explored. Here we report that neural-specific inactivation of two murine post …
PUMILIO proteins promote colorectal cancer growth via suppressing p21
Y Gong, Z Liu, Y Yuan, Z Yang, J Zhang, Q Lu… - Nature …, 2022 - nature.com
PUMILIO (PUM) proteins belong to the highly conserved PUF family post-transcriptional
regulators involved in diverse biological processes. However, their function in …
regulators involved in diverse biological processes. However, their function in …