PGC-1α activity and mitochondrial dysfunction in preterm infants

A Mohammadi, R Higazy, EB Gauda - Frontiers in Physiology, 2022 - frontiersin.org
Extremely low gestational age neonates (ELGANs) are born in a relatively hyperoxic
environment with weak antioxidant defenses, placing them at high risk for mitochondrial …

Statins decrease programmed death-ligand 1 (PD-L1) by inhibiting AKT and β-catenin signaling

WJ Lim, M Lee, Y Oh, XQ Fang, S Lee, CH Lim, J Park… - Cells, 2021 - mdpi.com
Retrospective observational studies have reported that statins improve clinical outcomes in
patients previously treated with programmed cell death protein 1 (PD-1)-targeting …

Protein stabilization of ITF2 by NF-κB prevents colitis-associated cancer development

M Lee, YS Kim, S Lim, SH Shin, I Kim, J Kim… - Nature …, 2023 - nature.com
Chronic colonic inflammation is a feature of cancer and is strongly associated with
tumorigenesis, but its underlying molecular mechanisms remain poorly understood …

Pleiotropic Regulation of PGC-1α in Tumor Initiation and Progression

Y Zhang, H Zhao, Y Li - Antioxidants & Redox Signaling, 2024 - liebertpub.com
Significance: Mitochondria are recognized as a central metabolic hub with bioenergetic,
biosynthetic, and signaling functions that tightly control key cellular processes. As a crucial …

PGC-1α drives small cell neuroendocrine cancer progression toward an ASCL1-expressing subtype with increased mitochondrial capacity

G Varuzhanyan, CC Chen, J Freeland, T He… - Proceedings of the …, 2024 - pnas.org
Adenocarcinomas from multiple tissues can converge to treatment-resistant small cell
neuroendocrine (SCN) cancers composed of ASCL1, POU2F3, NEUROD1, and YAP1 …

IL-33 stimulates the anticancer activities of eosinophils through extracellular vesicle-driven reprogramming of tumor cells

AR Gambardella, C Antonucci, C Zanetti, F Noto… - Journal of Experimental …, 2024 - Springer
Immune cell-derived extracellular vesicles (EV) affect tumor progression and hold promise
for therapeutic applications. Eosinophils are major effectors in Th2-related pathologies …

Construction and experimental validation of a macrophage cell senescence-related gene signature to evaluate the prognosis, immunotherapeutic sensitivity, and …

Q Jiang, J Zhou, Q Chen, Y Huang, C Yang… - Functional & Integrative …, 2023 - Springer
Tumor-associated macrophages (TAMs) are pivotal components of tumor microenvironment
(TME), and senescent TAMs contribute to the alternation of the profiles of TME. However, the …

Polygonum cuspidatum Extract (Pc-Ex) Containing Emodin Suppresses Lung Cancer-Induced Cachexia by Suppressing TCF4/TWIST1 Complex-Induced PTHrP …

XQ Fang, YS Kim, YM Lee, M Lee, WJ Lim, WJ Yim… - Nutrients, 2022 - mdpi.com
Cachexia, which is characterised by the wasting of fat and skeletal muscles, is the most
common risk factor for increased mortality rates among patients with advanced lung cancer …

Stage-Dependent Changes of Visual Function and Electrical Response of the Retina in the rd10 Mouse Model

S Cha, J Ahn, Y Jeong, YH Lee, HK Kim… - Frontiers in Cellular …, 2022 - frontiersin.org
One of the critical prerequisites for the successful development of retinal prostheses is
understanding the physiological features of retinal ganglion cells (RGCs) in the different …

Characterization of the molecular alterations induced by the prolonged exposure of normal colon mucosa and colon cancer cells to low-dose bisphenol A

VA Nair, LJB Malhab, WM Abdel-Rahman - International Journal of …, 2022 - mdpi.com
Colorectal cancer is a common cancer with a poor prognosis in both males and females.
The influence of bisphenol A (BPA), a widely used environmental contaminant, in colon …