Calcium (Ca 2+) is an essential ligand that binds its primary intracellular receptor calmodulin
(CaM) to trigger a variety of downstream processes and pathways. Central to the actions of …

Ca2+/calmodulin-dependent protein kinase kinase (CaMKK) is the activating kinase for
multiple downstream kinases, including CaM-kinase I (CaMKI), CaM-kinase IV (CaMKIV) …

Objective The AMP-activated protein kinase (AMPK) gets activated in response to energetic
stress such as contractions and plays a vital role in regulating various metabolic processes …

Current pharmacological treatments for bipolar disorder are inadequate and based on
serendipitously discovered drugs often with limited efficacy, burdensome side-effects, and …

The calcium-calmodulin–dependent protein kinase kinase-2 (CaMKK2) is a key regulator of
cellular and whole-body energy metabolism. It is known to be activated by increases in …

Binding of calcium to its intracellular receptor calmodulin (CaM) activates a family of
Ca2+/CaM-dependent protein kinases. CaMKK2 (Ca2+/CaM-dependent protein kinase …

Abstract Background The calcium (Ca2+)/calmodulin (CAM)-activated kinase kinase 2
(CAMKK2)-signaling regulates several physiological processes, for example, glucose …

Abstract Calcium (Ca2+) ions are ubiquitous and indispensable signaling messengers that
regulate virtually every cell function. The unique ability of Ca2+ to regulate so many different …

The calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) activates CAMK1,
CAMK4, AMPK, and AKT, leading to numerous physiological responses. The deregulation of …

Depression is a common and complex psychiatric illness with considerable heritability.
Genome-wide association studies (GWAS) have been conducted among different definitions …