[HTML][HTML] IL-1 family members mediate cell death, inflammation and angiogenesis in retinal degenerative diseases

Y Wooff, SM Man, R Aggio-Bruce, R Natoli… - Frontiers in …, 2019 - frontiersin.org
Inflammation underpins and contributes to the pathogenesis of many retinal degenerative
diseases. The recruitment and activation of both resident microglia and recruited …

An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and age-related …

GS Hageman, PJ Luthert, NHV Chong… - Progress in retinal and …, 2001 - Elsevier
Age-related macular degeneration (AMD) is a blinding disease that afflicts millions of adults
in the Western world. Although it has been proposed that a threshold event occurs during …

Evolution of geographic atrophy of the retinal pigment epithelium

JP Sarks, SH Sarks, MC Killingsworth - Eye, 1988 - nature.com
The aim of this study was to trace the evolution of geographic atrophy (GA) by clinical
documentation and by clinico-morphological correlation in representative eyes. Geographic …

Drusen associated with aging and age‐related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis …

RF Mullins, SR Russell, DH Anderson… - The FASEB …, 2000 - Wiley Online Library
Age‐related macular degeneration (AMD), a blinding disorder that compromises central
vision, is characterized by the accumulation of extracellular deposits, termed drusen …

RPE necroptosis in response to oxidative stress and in AMD

J Hanus, C Anderson, S Wang - Ageing research reviews, 2015 - Elsevier
Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in
the elderly. The underlying mechanism of non-neovascular AMD (dry AMD), also named …

Pathophysiology of age-related macular degeneration

RW Young - Survey of ophthalmology, 1987 - Elsevier
The clinical and histopathological features of age-related macular degeneration (AMD)
include a relationship with age, and the presence of pigmentary disturbances, drusen …

Complement activation and choriocapillaris loss in early AMD: implications for pathophysiology and therapy

SS Whitmore, EH Sohn, KR Chirco, AV Drack… - Progress in retinal and …, 2015 - Elsevier
Age-related macular degeneration (AMD) is a common and devastating disease that can
result in severe visual dysfunction. Over the last decade, great progress has been made in …

Age-related macular degeneration histopathologic studies: the 1992 Lorenz E. Zimmerman Lecture

WR Green, C Enger - Retina, 2005 - journals.lww.com
Background: Delineation qf the morphologic aspects of age-related macular degeneration
(ARMD) is helpful in correlation with the clinical features and may contribute to …

Age-related macular degeneration revisited–piecing the puzzle: the LXIX Edward Jackson memorial lecture

JW Miller - American journal of ophthalmology, 2013 - Elsevier
PURPOSE: To present the current understanding of age-related macular degeneration
(AMD) pathogenesis, based on clinical evidence, epidemiologic data, histopathologic …

Immunological and aetiological aspects of macular degeneration

PL Penfold, MC Madigan, MC Gillies… - Progress in retinal and eye …, 2001 - Elsevier
Aetiological and immunological aspects of AMD, a leading cause of blindness in Western
countries, have been reviewed. Developmental studies suggest that anatomical features …