This article focuses on the role of Rho family GTPases, particularly Rac1 and Rac1b in TGF‐
β‐induced epithelial‐mesenchymal transition (EMT) and EMT‐associated responses such …

Breast cancer is a heterogeneous disease comprised of at least five major tumor subtypes
that coalesce as the second leading cause of cancer death in women in the United States …

Cancer progression and metastasis are processes that involve significant cellular changes.
Many of these changes include alterations in the activity of the Rho GTPase family of …

The basal-like breast cancer (BLBC) subtype accounts for a disproportionately high
percentage of overall breast cancer mortality. The current therapeutic options for BLBC need …

The formation and stability of epithelial adhesive systems, such as adherens junctions,
desmosomes and tight junctions, rely on a number of cellular processes that ensure a …

Background Estrogen receptor β (ERβ) is expressed in the majority of invasive breast cancer
cases, irrespective of their subtype, including triple-negative breast cancer (TNBC). Thus …

Motile cells are capable of sensing the stiffness of the surrounding extracellular matrix
through integrin-mediated focal adhesions and migrate towards regions of higher rigidity in …

The loss of E-cadherin causes dysfunction of the cell–cell junction machinery, which is an
initial step in epithelial-to-mesenchymal transition (EMT), facilitating cancer cell invasion and …

Transforming growth factor-β (TGF-β) is a ubiquitous cytokine playing an essential role in
cell proliferation, differentiation, apoptosis, adhesion and invasion, as well as in cellular …

High mortality of prostate cancer patients is primarily due to metastasis. Understanding the
mechanisms controlling metastatic processes remains essential to develop novel therapies …