Cancer stem cells (CSCs) show a self-renewal capacity and differentiation potential that
contribute to tumor progression and therapy resistance. However, the underlying processes …

Embryonic stem cells and induced pluripotent stem cells hold great promise for regenerative
medicine. These cells can be propagated in culture in an undifferentiated state but can be …

Despite their fundamental biological and clinical importance, the molecular mechanisms that
regulate the first cell fate decisions in the human embryo are not well understood. Here we …

Oct4 is a mammalian POU transcription factor expressed by early embryo cells and germ
cells. We report that the activity of Oct4 is essential for the identity of the pluripotential …

Cell fate during development is defined by transcription factors that act as molecular
switches to activate or repress specific gene expression programmes. The POU transcription …

Oct4 and Nanog are transcription factors required to maintain the pluripotency and self-
renewal of embryonic stem (ES) cells. Using the chromatin immunoprecipitation paired-end …

Transcription factors are regulatory proteins that either activate or repress the transcription of
genes via binding to DNA regulatory sequences and regulating recruitment of transcriptional …

Human and mouse embryonic stem cells (HESCs and MESCs, respectively) self-renew
indefinitely while maintaining the ability to generate all three germ-layer derivatives. Despite …

The incorporation of histone H3 variants has been implicated in the epigenetic memory of
cellular state. Using genome editing with zinc-finger nucleases to tag endogenous H3. 3, we …

The Xist gene has been proposed as a candidate for the X inactivation centre, the master
regulatory switch locus that controls X chromosome inactivation. So far this hypothesis has …