From SARS to MERS, thrusting coronaviruses into the spotlight

Z Song, Y Xu, L Bao, L Zhang, P Yu, Y Qu, H Zhu… - viruses, 2019 - mdpi.com
Coronaviruses (CoVs) have formerly been regarded as relatively harmless respiratory
pathogens to humans. However, two outbreaks of severe respiratory tract infection, caused …

Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology

R Channappanavar, S Perlman - Seminars in immunopathology, 2017 - Springer
Human coronaviruses (hCoVs) can be divided into low pathogenic and highly pathogenic
coronaviruses. The low pathogenic CoVs infect the upper respiratory tract and cause mild …

Comparative tropism, replication kinetics, and cell damage profiling of SARS-CoV-2 and SARS-CoV with implications for clinical manifestations, transmissibility, and …

H Chu, JFW Chan, TTT Yuen, H Shuai, S Yuan… - The Lancet …, 2020 - thelancet.com
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was reported
from China in January, 2020. SARS-CoV-2 is efficiently transmitted from person to person …

Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model

B Rockx, T Kuiken, S Herfst, T Bestebroer, MM Lamers… - Science, 2020 - science.org
The current pandemic coronavirus, severe acute respiratory syndrome–coronavirus 2
(SARS-CoV-2), was recently identified in patients with an acute respiratory syndrome …

Bat origin of human coronaviruses

B Hu, X Ge, LF Wang, Z Shi - Virology journal, 2015 - Springer
Bats have been recognized as the natural reservoirs of a large variety of viruses. Special
attention has been paid to bat coronaviruses as the two emerging coronaviruses which have …

Effective inhibition of MERS-CoV infection by resveratrol

SC Lin, CT Ho, WH Chuo, S Li, TT Wang… - BMC infectious diseases, 2017 - Springer
Abstract Background Middle East Respiratory Syndrome coronavirus (MERS-CoV) is an
emerging viral pathogen that causes severe morbidity and mortality. Up to date, there is no …

Middle East respiratory syndrome coronavirus causes multiple organ damage and lethal disease in mice transgenic for human dipeptidyl peptidase 4

K Li, C Wohlford-Lenane, S Perlman… - The Journal of …, 2016 - academic.oup.com
Middle East respiratory syndrome coronavirus (MERS-CoV) causes life-threatening disease.
Dipeptidyl peptidase 4 (DPP4) is the receptor for cell binding and entry. There is a need for …

Recent advances in the vaccine development against Middle East respiratory syndrome-coronavirus

CY Yong, HK Ong, SK Yeap, KL Ho… - Frontiers in microbiology, 2019 - frontiersin.org
Middle East respiratory syndrome (MERS) is a deadly viral respiratory disease caused by
MERS-coronavirus (MERS-CoV) infection. To date, there is no specific treatment proven …

MERS-CoV: understanding the latest human coronavirus threat

A Chafekar, BC Fielding - Viruses, 2018 - mdpi.com
Human coronaviruses cause both upper and lower respiratory tract infections in humans. In
2012, a sixth human coronavirus (hCoV) was isolated from a patient presenting with severe …

Co-circulation of three camel coronavirus species and recombination of MERS-CoVs in Saudi Arabia

JSM Sabir, TTY Lam, MMM Ahmed, L Li, Y Shen… - Science, 2016 - science.org
Outbreaks of Middle East respiratory syndrome (MERS) raise questions about the
prevalence and evolution of the MERS coronavirus (CoV) in its animal reservoir. Our …