Mechanical Regulation of Polymer Gels

C Xu, Y Chen, S Zhao, D Li, X Tang, H Zhang… - Chemical …, 2024 - ACS Publications
The mechanical properties of polymer gels devote to emerging devices and machines in
fields such as biomedical engineering, flexible bioelectronics, biomimetic actuators, and …

Cellular physiology and pathophysiology of EAAT anion channels

P Kovermann, M Engels, F Müller… - Frontiers in cellular …, 2022 - frontiersin.org
Excitatory amino acid transporters (EAATs) optimize the temporal resolution and energy
demand of mammalian excitatory synapses by quickly removing glutamate from the synaptic …

Structural insights into inhibitory mechanism of human excitatory amino acid transporter EAAT2

T Kato, T Kusakizako, C Jin, X Zhou, R Ohgaki… - Nature …, 2022 - nature.com
Glutamate is a pivotal excitatory neurotransmitter in mammalian brains, but excessive
glutamate causes numerous neural disorders. Almost all extracellular glutamate is retrieved …

Structural basis of the obligatory exchange mode of human neutral amino acid transporter ASCT2

AM Borowska, MG Chiariello, AA Garaeva… - Nature …, 2024 - nature.com
ASCT2 is an obligate exchanger of neutral amino acids, contributing to cellular amino acid
homeostasis. ASCT2 belongs to the same family (SLC1) as Excitatory Amino Acid …

Human XPR1 structures reveal phosphate export mechanism

R Yan, H Chen, C Liu, J Zhao, D Wu, J Jiang, J Gong… - Nature, 2024 - nature.com
Inorganic phosphate (Pi) is a fundamental macronutrient for all living organisms, the
homeostasis of which is critical for numerous biological activities,–. As the only known …

Symport and antiport mechanisms of human glutamate transporters

B Qiu, O Boudker - Nature Communications, 2023 - nature.com
Excitatory amino acid transporters (EAATs) uptake glutamate into glial cells and neurons.
EAATs achieve million-fold transmitter gradients by symporting it with three sodium ions and …

Importance of the catalyst–water Coulomb interaction for oxygen reduction reaction kinetics

T Liu, Y Zhao, T Zhai - Energy & Environmental Science, 2024 - pubs.rsc.org
We identify an important new factor affecting oxygen reduction reaction (ORR) kinetics (ie,
the catalyst–water Coulomb interaction). A stronger Coulomb interaction leads to a stronger …

Proton-driven alternating access in a spinster lipid transporter

R Dastvan, A Rasouli… - Nature …, 2022 - nature.com
Spinster (Spns) lipid transporters are critical for transporting sphingosine-1-phosphate (S1P)
across cellular membranes. In humans, Spns2 functions as the main S1P transporter in …

Structures and mechanisms of the Arabidopsis cytokinin transporter AZG1

L Xu, W Jia, X Tao, F Ye, Y Zhang, ZJ Ding, SJ Zheng… - Nature Plants, 2024 - nature.com
Cytokinins are essential for plant growth and development, and their tissue distributions are
regulated by transmembrane transport. Recent studies have revealed that members of the …

Structural basis of ligand binding modes of human EAAT2

Z Zhang, H Chen, Z Geng, Z Yu, H Li, Y Dong… - Nature …, 2022 - nature.com
In the central nervous system (CNS), excitatory amino acid transporters (EAATs) mediate the
uptake of excitatory neurotransmitter glutamate and maintain its low concentrations in the …