Breast cancer (BC) is the leading cause of cancer-related mortality in women, only followed
by lung cancer. Given the importance of BC in public health, it is essential to identify …

Among the different types of breast cancers, triple-negative breast cancers (TNBCs) are
highly aggressive, do not respond to conventional hormonal/human epidermal growth factor …

GLI transcription factors have important roles in intracellular signaling cascade, acting as the
main mediators of the HH-GLI signaling pathway. This is one of the major developmental …

BC (BC), as the most common malignancy in women worldwide, is associated with high
morbidity and mortality. However, chemoresistance and toxicity are the main causes that …

Estrogen receptor (ER) α‐positive breast cancer cells regulate the expression of estrogen‐
responsive genes, which are involved in cell proliferation, differentiation, and cell cycle …

Abstract Forkhead box M1 (FOXM1) and hedgehog (Hh) signaling pathway are implicated in
the formation and development of human tumors, including cervical cancer. Previous studies …

Hedgehog signaling pathway has been implicated in the pathology of ovarian cancer, and
Survivin (BIRC5) has been suggested as a novel target of this pathway. Herein we …

The epithelium of the lactiferous ducts in the breast is comprised of luminal epithelial cells
and underlying basal myoepithelial cells. The regulation of cell fate and transit of cells …

Featured Application Targeting interaction between sonic hedgehog protein and sex
hormone receptors might be a valuable strategy for the treatment of endocrine-resistant …

Gli proteins are key transcription factors of the Hedgehog (HH) signaling pathway, which is
associated with tumorigenesis and drug resistance. However, the role of the HH signaling …