Application of approved cisplatin derivatives in combination therapy against different cancer diseases

D Tsvetkova, S Ivanova - Molecules, 2022 - mdpi.com
The problems with anticancer therapy are resistance and toxicity. From 3000 Cisplatin
derivatives tested as antitumor agents, most of them have been rejected, due to toxicity. The …

Statistical methods and data visualisation of patient-reported outcomes in early phase dose-finding oncology trials: a methodological review

E Alger, A Minchom, OL Aiyegbusi, M Schipper… - …, 2023 - thelancet.com
Background Traditionally, within dose-finding clinical trials, treatment toxicity and tolerability
are assessed by clinicians. Research has shown that clinician reporting may have …

Gastric Cancer (GC) with Peritoneal Metastases (PMs): An Overview of Italian PSM Oncoteam Evidence and Study Purposes

P Sammartino, G De Manzoni, L Marano, D Marrelli… - Cancers, 2023 - mdpi.com
Simple Summary Peritoneal metastases (PMs), arising from gastric cancer (GC), are one of
the most common patterns of synchronous and metachronous dissemination and are …

Phase 1 trial of intraperitoneal paclitaxel in combination with intravenous cisplatin and oral capecitabine in patients with advanced gastric cancer and peritoneal …

S Vatandoust, T Bright, AC Roy… - Asia‐Pacific Journal …, 2022 - Wiley Online Library
Aims Gastric cancer with peritoneal involvement has a poor prognosis. Intraperitoneal (IP)
paclitaxel has shown promising results in these patients. However, this approach has only …

[HTML][HTML] Gastric adenocarcinoma peritoneal carcinomatosis: a narrative review

BL Green, JL Davis - Digestive medicine research, 2022 - ncbi.nlm.nih.gov
Methods: A search of PubMed and Google Scholar databases was performed for the terms
“Gastric Adenocarcinoma Peritoneal Carcinomatosis” for English articles published between …

腹腔灌注化疗在胃癌综合治疗中的价值

程曦, 方勇 - 肿瘤综合治疗电子杂志, 2020 - jmcm2018.com
腹膜转移是胃癌的主要致死原因. 近年来, 部分临床研究证实包含腹腔灌注化疗的综合治疗可
改善胃癌患者预后, 降低根治术后转移风险, 也可改善并延长已存在腹膜转移患者的生存时间 …

Study protocol of a phase 1 clinical trial establishing the safety of intrapleural administration of liposomal curcumin: curcumin as a palliative treatment for malignant …

AJ Hocking, AL Farrall, S Newhouse, P Sordillo… - BMJ open, 2021 - bmjopen.bmj.com
Introduction This is a phase 1, open-label, single-centre, uncontrolled, dose-escalation study
to evaluate the feasibility, tolerability and pharmacokinetic profiles of a single dose of …

[PDF][PDF] Statistical methods and data visualisation of patient-reported outcomes in early phase dose-finding oncology trials

E Alger, A Minchom, OL Aiyegbusi, M Schipper, C Yap - 2023 - research.birmingham.ac.uk
Background Traditionally, within dose-finding clinical trials, treatment toxicity and tolerability
are assessed by clinicians. Research has shown that clinician reporting may have …

[PDF][PDF] Gastric adenocarcinoma peritoneal carcinomatosis: a narrative

BL Green, JL Davis - 2022 - cdn.amegroups.cn
Gastric adenocarcinoma peritoneal carcinomatosis: a narrative review Page 1 Page 1 of 12
© Digestive Medicine Research. All rights reserved. Dig Med Res 2022;5:37 | https://dx.doi.org/10.21037/dmr-21-94 …

[HTML][HTML] Protocol: Study protocol of a phase 1 clinical trial establishing the safety of intrapleural administration of liposomal curcumin: curcumin as a palliative treatment …

AJ Hocking, AL Farrall, S Newhouse, P Sordillo… - BMJ Open, 2021 - ncbi.nlm.nih.gov
Introduction This is a phase 1, open-label, singlecentre, uncontrolled, dose-escalation study
to evaluate the feasibility, tolerability and pharmacokinetic profiles of a single dose of …