Mixed lineage leukemia is a very aggressive blood cancer that predominantly occurs in
pediatric patients. In contrast to other types of childhood acute leukemias, mixed lineage …

Retroviral integrases catalyze two reactions, 3′-processing of viral DNA ends, followed by
integration of the processed ends into chromosomal DNA. X-ray crystal structures of …

Integrase is an essential retroviral enzyme that binds both termini of linear viral DNA and
inserts them into a host cell chromosome. The structure of full-length retroviral integrase …

The multifunctional HIV-1 enzyme integrase interacts with viral DNA and its key cellular
cofactor LEDGF to effectively integrate the reverse transcript into a host cell chromosome …

Human immunodeficiency virus type 1 (HIV-1) displays the unique ability to infect
nondividing cells. The capsid of HIV-1 is the viral determinant for viral nuclear import. To …

The intasome is the basic recombination unit of retroviral integration, comprising the
integrase protein and the ends of the viral DNA made by reverse transcription. Clinical …

Abstract Background LEDGF/p75 (LEDGF) is the main cellular cofactor of HIV-1 integrase
(IN). It acts as a tethering factor for IN, and targets the integration of HIV in actively …

DNA rearrangements are important in genome function and evolution. Genetic material can
be rearranged inadvertently during processes such as DNA repair, or can be moved in a …

Experimental evidence suggests that a tetramer of integrase (IN) is the protagonist of the
concerted strand transfer reaction, whereby both ends of retroviral DNA are inserted into a …

Three-dimensional macromolecular structures shed critical light on biological mechanism
and facilitate development of small molecule inhibitors. Clinical success of raltegravir, a …