Optogenetics for light control of biological systems

V Emiliani, E Entcheva, R Hedrich… - Nature Reviews …, 2022 - nature.com
Optogenetic techniques have been developed to allow control over the activity of selected
cells within a highly heterogeneous tissue, using a combination of genetic engineering and …

Optogenetics at the presynapse

BR Rost, J Wietek, O Yizhar, D Schmitz - Nature neuroscience, 2022 - nature.com
Optogenetic actuators enable highly precise spatiotemporal interrogation of biological
processes at levels ranging from the subcellular to cells, circuits and behaving organisms …

Social trauma engages lateral septum circuitry to occlude social reward

L Li, R Durand-de Cuttoli, AV Aubry, CJ Burnett… - Nature, 2023 - nature.com
In humans, traumatic social experiences can contribute to psychiatric disorders. It is
suggested that social trauma impairs brain reward function such that social behaviour is no …

BiPOLES is an optogenetic tool developed for bidirectional dual-color control of neurons

J Vierock, S Rodriguez-Rozada, A Dieter… - Nature …, 2021 - nature.com
Optogenetic manipulation of neuronal activity through excitatory and inhibitory opsins has
become an indispensable experimental strategy in neuroscience research. For many …

Wireless, battery-free implants for electrochemical catecholamine sensing and optogenetic stimulation

T Stuart, WJ Jeang, RA Slivicki, BJ Brown, A Burton… - ACS …, 2022 - ACS Publications
Neurotransmitters and neuromodulators mediate communication between neurons and
other cell types; knowledge of release dynamics is critical to understanding their …

Efficient optogenetic silencing of neurotransmitter release with a mosquito rhodopsin

M Mahn, I Saraf-Sinik, P Patil, M Pulin, E Bitton… - Neuron, 2021 - cell.com
Information is carried between brain regions through neurotransmitter release from axonal
presynaptic terminals. Understanding the functional roles of defined neuronal projection …

Lights, fiber, action! A primer on in vivo fiber photometry

EH Simpson, T Akam, T Patriarchi, M Blanco-Pozo… - Neuron, 2024 - cell.com
Fiber photometry is a key technique for characterizing brain-behavior relationships in vivo.
Initially, it was primarily used to report calcium dynamics as a proxy for neural activity via …

[HTML][HTML] A central alarm system that gates multi-sensory innate threat cues to the amygdala

SJ Kang, S Liu, M Ye, DI Kim, GM Pao, BA Copits… - Cell reports, 2022 - cell.com
Perception of threats is essential for survival. Previous findings suggest that parallel
pathways independently relay innate threat signals from different sensory modalities to …

Local modulation by presynaptic receptors controls neuronal communication and behaviour

DM Lovinger, Y Mateo, KA Johnson, SA Engi… - Nature Reviews …, 2022 - nature.com
Central nervous system neurons communicate via fast synaptic transmission mediated by
ligand-gated ion channel (LGIC) receptors and slower neuromodulation mediated by G …

Rhodopsins at a glance

T Nagata, K Inoue - Journal of Cell Science, 2021 - journals.biologists.com
Rhodopsins are photoreceptive membrane proteins consisting of a common heptahelical
transmembrane architecture that contains a retinal chromophore. Rhodopsin was first …