The electromechanical function of the heart involves complex, coordinated activity over time
and space. Life-threatening cardiac arrhythmias arise from asynchrony in these space–time …

Mammalian models including non‐human primates, pigs and rodents have been used
extensively to study the mechanisms of cardiovascular disease. However, there is an …

The limited per-pixel bandwidth of most microscopy methods requires compromises
between field of view, sampling density and imaging speed. This limitation constrains …

Tissue-wide electrophysiology with single-cell and millisecond spatiotemporal resolution is
critical for heart and brain studies. Issues arise, however, from the invasive, localized …

The ability to visualize and quantitatively measure dynamic biological processes in vivo and
at high spatiotemporal resolution is of fundamental importance to experimental …

The contractility of cardiac cells is a key parameter that describes the biomechanical
characteristics of the beating heart, but functional monitoring of three-dimensional cardiac …

Recent advances in heart-on-a-chip systems hold great promise to facilitate cardiac
physiological, pathological, and pharmacological studies. This review focuses on the …

Complex disordered matter is of central importance to a wide range of disciplines, from
bacterial colonies and embryonic tissues in biology to foams and granular media in …

Fast volumetric imaging is essential for understanding the function of excitable tissues such
as those found in the brain and heart. Measuring cardiac voltage transients in tissue …

Despite ongoing efforts in cardiovascular research, the acquisition of high-resolution and
high-speed images for the purpose of assessing cardiac contraction remains challenging …