One of the most common chronic liver disorders, affecting mainly people in Western
countries, is nonalcoholic fatty liver disease (NAFLD). Unfortunately, its pathophysiological …

Obesity has been recognized to increase the risk of such diseases as cardiovascular
diseases, diabetes, and cancer. It indicates that obesity can impact genome stability …

Mitochondrial DNA (mtDNA) escaping stressed mitochondria provokes inflammation via
cGAS-STING pathway activation and, when oxidized (Ox-mtDNA), it binds cytosolic NLRP3 …

As the primary cellular location for respiration and energy production, mitochondria serve in
a critical capacity to the cell. Yet, by virtue of this very function of respiration, mitochondria …

Oxidative stress and the resulting damage to genomic DNA are inevitable consequences of
endogenous physiological processes, and they are amplified by cellular responses to …

Genomic DNA is susceptible to endogenous and environmental stresses that modify DNA
structure and its coding potential. Correspondingly, cells have evolved intricate DNA repair …

A large percentage of redox-responsive gene promoters contain evolutionarily conserved
guanine-rich clusters; guanines are the bases most susceptible to oxidative modification (s) …

Rationale: Activation of NLRP3 (nucleotide-binding domain and leucine-rich repeat pyrin
domain containing 3) inflammasome-mediating interleukin (IL)-1β secretion has emerged as …

Insulin resistance (IR), a key component of the metabolic syndrome, precedes the
development of diabetes, cardiovascular disease, and Alzheimer's disease. Its etiological …

The decrease in cognitive/motor functions and physical abilities severely affects the aging
population in carrying out daily activities. These disabilities become a burden on individuals …