Osteomyelitis is a destructive disease of bone tissue caused by infection with pathogenic
microorganisms. Because of the complex and long‐term abnormal conditions, osteomyelitis …

Metabolites are the small biological molecules involved in energy conversion and
biosynthesis. Studying metabolism is inherently challenging due to metabolites' reactivity …

The rise of antibiotic resistance and declining discovery of new antibiotics has created a
global health crisis. Of particular concern, no new antibiotic classes have been approved for …

NADPH donates high-energy electrons for antioxidant defence and reductive biosynthesis.
Cytosolic NADP is recycled to NADPH by the oxidative pentose-phosphate pathway …

The field of photopharmacology aims to introduce smart drugs that, through the
incorporation of molecular photoswitches, allow for the remote spatial and temporal control …

The biguanide drug metformin is widely prescribed to treat type 2 diabetes and metabolic
syndrome, but its mode of action remains uncertain. Metformin also increases lifespan in …

Warburg's observation that cancer cells exhibit a high rate of glycolysis even in the presence
of oxygen (aerobic glycolysis) sparked debate over the role of glycolysis in normal and …

The explosion of sequence information in bacteria makes developing high-throughput, cost-
effective approaches to matching genes with phenotypes imperative. Using E. coli as proof …

Fluoropyrimidines are the first-line treatment for colorectal cancer, but their efficacy is highly
variable between patients. We queried whether gut microbes, a known source of inter …

Metabolism is vital to every aspect of cell function, yet the metabolome of induced pluripotent
stem cells (iPSCs) remains largely unexplored. Here we report, using an untargeted …