As an important sensor in the innate immune system, NLRP3 detects exogenous pathogenic
invasions and endogenous cellular damage and responds by forming the NLRP3 …

Pyroptosis, apoptosis and necroptosis are the most genetically well-defined programmed
cell death (PCD) pathways, and they are intricately involved in both homeostasis and …

Inflammasomes are cytosolic innate immune complexes that activate caspase-1 following
detection of pathogenic and endogenous dangers,,,–, and NACHT-, leucine-rich repeat …

NLRP3 is the best characterized cytosolic nod-like pattern recognition receptor which can
detect microbial motifs, endogenous danger and stress signals. Activation of NLRP3 leads to …

The NLRP3 inflammasome can be activated by stimuli that include nigericin, uric acid
crystals, amyloid-β fibrils and extracellular ATP. The mitotic kinase NEK7 licenses the …

NLRP6 is important in host defense by inducing functional outcomes including
inflammasome activation and interferon production. Here, we show that NLRP6 undergoes …

Abstract The NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) inflammasome is
an immunological sensor that detects a wide range of microbial-and host-derived signals …

Caspase-11 detection of intracellular lipopolysaccharide (LPS) from invasive Gram-negative
bacteria mediates noncanonical activation of the NLRP3 inflammasome. While avirulent …

Inflammasomes are multi-component signaling complexes critical to the initiation of
pyroptotic cell death in response to invading pathogens and cellular damage. A number of …

In multicellular organisms the regulated cell death apoptosis is critically important for both
ontogeny and homeostasis. Mitochondria are indispensable for stress-induced apoptosis …