Understanding the drivers of MHC restriction of T cell receptors
T cell discrimination of self and non-self is predicated on αβ T cell receptor (TCR) co-
recognition of peptides presented by MHC molecules. Over the past 20 years, structurally …
recognition of peptides presented by MHC molecules. Over the past 20 years, structurally …
Structural understanding of T cell receptor triggering
X Xu, H Li, C Xu - Cellular & Molecular Immunology, 2020 - nature.com
The T cell receptor (TCR) is one of the most complicated receptors in mammalian cells, and
its triggering mechanism remains mysterious. As an octamer complex, TCR comprises an …
its triggering mechanism remains mysterious. As an octamer complex, TCR comprises an …
Physicochemical characterization and immunomodulatory activity of sulfated Chinese yam polysaccharide
A sulfated Chinese yam polysaccharide (S-CYP) was obtained from non-starch Chinese
yam polysaccharide (CYP) by chlorosulfonic acid-pyridine (CSA-Pyr) method. The …
yam polysaccharide (CYP) by chlorosulfonic acid-pyridine (CSA-Pyr) method. The …
[HTML][HTML] Structure of a fully assembled tumor-specific T cell receptor ligated by pMHC
L Sušac, MT Vuong, C Thomas, S von Bülow… - Cell, 2022 - cell.com
The T cell receptor (TCR) expressed by T lymphocytes initiates protective immune
responses to pathogens and tumors. To explore the structural basis of how TCR signaling is …
responses to pathogens and tumors. To explore the structural basis of how TCR signaling is …
Sulfated modification enhances the immunomodulatory effect of Cyclocarya paliurus polysaccharide on cyclophosphamide-induced immunosuppressed mice through …
The present study investigated the effect of sulfation on the immunomodulatory effect of
Cyclocarya paliurus polysaccharide (CP) through a Cyclophosphamide (CTX)-induced …
Cyclocarya paliurus polysaccharide (CP) through a Cyclophosphamide (CTX)-induced …
In vitro reconstitution of T cell receptor-mediated segregation of the CD45 phosphatase
T cell signaling initiates upon the binding of peptide-loaded MHC (pMHC) on an antigen-
presenting cell to the T cell receptor (TCR) on a T cell. TCR phosphorylation in response to …
presenting cell to the T cell receptor (TCR) on a T cell. TCR phosphorylation in response to …
The role of molecular flexibility in antigen presentation and T cell receptor-mediated signaling
K Natarajan, J Jiang, NA May, MG Mage… - Frontiers in …, 2018 - frontiersin.org
Antigen presentation is a cellular process that involves a number of steps, beginning with
the production of peptides by proteolysis or aberrant synthesis and the delivery of peptides …
the production of peptides by proteolysis or aberrant synthesis and the delivery of peptides …
Reversed T cell receptor docking on a major histocompatibility class I complex limits involvement in the immune response
The anti-viral T cell response is drawn from the naive T cell repertoire. During influenza
infection, the CD8+ T cell response to an H-2D b-restricted nucleoprotein epitope (NP 366) …
infection, the CD8+ T cell response to an H-2D b-restricted nucleoprotein epitope (NP 366) …
Allosteric activation of T cell antigen receptor signaling by quaternary structure relaxation
AL Lanz, G Masi, N Porciello, A Cohnen, D Cipria… - Cell reports, 2021 - cell.com
The mechanism of T cell antigen receptor (TCR-CD3) signaling remains elusive. Here, we
identify mutations in the transmembrane region of TCRβ or CD3ζ that augment peptide …
identify mutations in the transmembrane region of TCRβ or CD3ζ that augment peptide …
The T cell antigen receptor α transmembrane domain coordinates triggering through regulation of bilayer immersion and CD3 subunit associations
Initial molecular details of cellular activation following αβT cell antigen receptor (TCR)
ligation by peptide-major histocompatibility complexes (pMHC) remain unexplored. We …
ligation by peptide-major histocompatibility complexes (pMHC) remain unexplored. We …