Chronic low-grade inflammation has a key role in the aging process, a state called
inflammaging. It is known that the chronic inflammatory condition generates counteracting …

Dendritic cells (DC) are antigen-presenting cells that can communicate with T cells both
directly and indirectly, regulating our adaptive immune responses against environmental …

Although carcinoma-associated fibroblasts (CAFs) in tumor microenvironments have a
critical role in immune cell modulation, their effects on the generation of regulatory dendritic …

Background The insulin/IGF-1 signaling pathway has a major role in the regulation of
longevity both in Caenorhabditis elegans and mammalian species, ie, reduced activity of …

We recognize well the abilities of dendritic cells to activate effector T cell (Teff cell)
responses to an array of antigens and think of these cells in this context as pre-eminent …

Naturally occurring CD4+ CD25high forkhead box protein 3 (FOXP3)+ regulatory T cells
(nTregs) are key mediators of immunity, which orchestrate and maintain tolerance to self and …

DC-mediated NKT cell activation is critical in initiating the immune response following
kidney ischemia/reperfusion injury (IRI), which mimics human acute kidney injury (AKI) …

Background The use of tolerogenic DCs is a promising therapeutic strategy for
transplantation and autoimmune disorders. Immunomodulatory DCs are primarily generated …

Dendritic cells (DC s) are specialized cells of the innate immune system that are
characterized by their ability to take up, process and present antigens (Ag) to effector T cells …

Fungi are abundant in the environment, causing our lungs to be constantly exposed to a
diverse range of species. While the majority of these are cleared effectively in healthy …