Enhanced behavioral response by decreasing brain oxidative stress to 6-hydroxy-l-nicotine in Alzheimer's disease rat model
Hydroxy-l-nicotine (6HLN) is a nicotine metabolite resulted from nicotine degradation within
Arthrobacter nicotinovorans with positive effects on spatial memory and oxidative stress …
Arthrobacter nicotinovorans with positive effects on spatial memory and oxidative stress …
In vitro stability and antioxidant potential of the neuprotective metabolite 6-hydroxy-nicotine
EM Mocanu, AL Mazarachi… - Journal of Experimental …, 2018 - jemb.bio.uaic.ro
Alzheimer's disease is complex, and it is unlikely that any one single drug or intervention
can successfully treat it. The implication of nicotinic acetylcholine receptors (nAChR) in …
can successfully treat it. The implication of nicotinic acetylcholine receptors (nAChR) in …
Steps towards an Arthrobacter nicotinovorans based biotechnology for production of 6-hidroxy-nicotine
G Mihalache, M Stefan, C Babii, D Motei… - International …, 2016 - search.proquest.com
As the archetypal agonist of nAchR, nicotine stands up as a powerful scaffold for developing
new Alzheimer disease therapeutic agents. In this context, the wide range of nicotine …
new Alzheimer disease therapeutic agents. In this context, the wide range of nicotine …
[PDF][PDF] Time dependent accumulation of nicotine derivatives in the culture medium of Arthrobacter nicotinovorans pAO1
R Boiangiu, D Guzun, M MIHASAN - … Ioan Cuza" din Iasi Sec. II a …, 2014 - jemb.bio.uaic.ro
Previous studies have shown that the metabolic intermediate 6-hidroxy-D-nicotine (6HNic)
found in the Arthrobacter nicotinovorans pAO1+ nicotine catabolic pathway has the ability to …
found in the Arthrobacter nicotinovorans pAO1+ nicotine catabolic pathway has the ability to …
[PDF][PDF] Cotinine and 6-hydroxy-L-nicotine mitigate the memory deficits and oxidative stress induced by brain infusion of Aβ
R Stefan - cercetare.bio.uaic.ro
Figure 5. Administration of 0.3 and 0.7 mg/kg of NIC (A, D), 6HLN (B, E) and COT (C, F) to
Aβ25-35-treated rats significantly improves the spatial memory in RAM task. The treatments …
Aβ25-35-treated rats significantly improves the spatial memory in RAM task. The treatments …
[PDF][PDF] MOLECULAR GENE CLONING OF NICOTINE-DEHIDROGENASE FROM THE pAO1 MEGAPLASMID OF ARTHROBACTER NICOTINOVORANS
A Andrei, M Mihasan - Journal of Experimental and Molecular …, 2013 - jemb.bio.uaic.ro
6-hydroxi-L-nicotine (6HNic) has an important potential as a drug for neuro-degenerative
disorders and a suitable simple and reliable method for obtaining contaminant-free 6HNic …
disorders and a suitable simple and reliable method for obtaining contaminant-free 6HNic …