Preeclampsia is a severe pregnancy complication globally, characterized by poor
placentation triggering vascular dysfunction. Matrix metalloproteinases (MMPs) exhibit …

Extravillous trophoblast remodeling of the uterine spiral arteries is essential for promoting
blood flow to the placenta and fetal development, but little is known about the regulation of …

Shallow extravillous trophoblast (EVT) invasion is central to the pathophysiology of many
pregnancy complications. Invasion is mediated partially by matrix metalloproteinases …

Abstract Purpose of Review The aim of the study is to perform a critical assessment of in vitro
models of pre-eclampsia using complementary human and cell line-based studies …

Type 1 diabetes mellitus (T1DM) is associated with reduced fetal growth in early pregnancy,
but a contributing role of the placenta has remained elusive. Thus, we investigated whether …

Abstract Purpose of Review Men and women differ in the prevalence, pathophysiology and
control rate of hypertension in an age-dependent manner. The renal endothelin system …

Membrane‐type matrix metalloproteinases (MT‐MMPs) are cell membrane‐tethered
proteinases that belong to the family of the MMPs. Apart from their roles in degradation of the …

The invasion of extravillous trophoblast (EVT) cells into the maternal decidua, which plays a
crucial role in the establishment of a successful pregnancy, is highly orchestrated by a …

Undifferentiated connective tissue diseases (UCTD s) are a heterogeneous group of
disorders characterized by symptoms and signs suggestive of systemic autoimmune …

During first trimester pregnancy, trophoblast cells invade from the placenta into the maternal
decidua where they anchor the placenta and remodel luminal structures like spiral arteries …