Systemic sclerosis (SSc) is a rare autoimmune connective tissue disease with multi-organ
involvement, fibrosis and vasculopathy. Treatment in SSc, including early diffuse cutaneous …

Systemic sclerosis (SSc; scleroderma) has the highest individual mortality of all rheumatic
diseases, and interstitial lung disease (ILD) is among the leading causes of SSc‐related …

Through their potential pro-fibrotic and pro-inflammatory properties, macrophages are at the
cross-road of key SSc pathogenic processes and associated manifestations. Investigative …

New molecular mechanisms that can be targeted with specific drugs have recently emerged
for the treatment of systemic sclerosis (SSc) patients. Over the past 3 years, the achievement …

Background Results from the double-blind phase 2 DESIRES trial showed that rituximab
improves skin thickening in systemic sclerosis. Here, we present the findings of a …

Systemic sclerosis (SSc) is a chronic autoimmune disease with a poor prognosis. Among the
various complications of SSc, treatment options for the fibrotic lesions, skin sclerosis, and …

Systemic sclerosis (SSc) is a systemic, immune-mediated chronic disorder characterized by
small vessel alterations and progressive fibrosis of the skin and internal organs. The …

Systemic sclerosis is the rheumatic disease with the highest individual mortality. The severity
of the disease is determined by the extent of fibrotic changes to cutaneous and internal …

ABSTRACT Introduction: Systemic sclerosis (SSc), also known as scleroderma, is a complex
orphan disease characterized by early inflammatory features, vascular hyper-reactivity, and …

В спектре механизмов хронического воспаления центральное место занимают два
фундаментальных патологических процесса-аутоиммунитет и аутовоспаление …