Anaphylaxis is an acute life-threatening systemic allergic reaction that can have a wide
range of clinical manifestations. The most common triggers for anaphylaxis include food …

The webinar series and workshop titled “Trust Your Gut: Establishing Confidence in
Gastrointestinal Models–An Overview of the State of the Science and Contexts of Use” was …

Food allergy is a pathological condition caused by a disruption of oral tolerance. This
condition leads to a pro-inflammatory environment that culminates in symptoms that varies …

Preclinical mouse models are widely used for studying mechanisms of disease and
responses to therapeutics, however there is concern about the lack of experimental …

Most B cells produced in the bone marrow have some level of autoreactivity. Despite efforts
of central tolerance to eliminate these cells, many escape to periphery, where in healthy …

Simple Summary Scientific research into the causes, progression, and treatment of disease
is dependent on the use of animal models. However, many scientists say that they cannot …

Vertical transmission of obesity is a critical contributor to the unabated obesity pandemic and
the associated surge in metabolic diseases. Existing experimental models insufficiently …

Ketogenic diets (KDs) are a popular tool used for weight management. Studies in mice have
demonstrated that KDs reduce food intake, increase energy expenditure and cause weight …

Allergic sensitization can occur after allergen exposure through the oral-mucosal or
cutaneous route. Allergic remission is associated with a decrease in total and specific IgE …