Microscale differential ion mobility spectrometry for field deployable chemical analysis

KMM Kabir, WA Donald - TrAC Trends in Analytical Chemistry, 2017 - Elsevier
Differential ion mobility spectrometry (DMS) has emerged to be particularly well suited for
the rapid and selective identification of gas phase ions at atmospheric pressure. DMS can …

Bioanalytical challenges and strategies for accurately measuring acyl glucuronide metabolites in biological fluids

SR Patel - Biomedical Chromatography, 2020 - Wiley Online Library
Bioanalysis of unstable compounds such as acyl glucuronide metabolites represents a great
analytical challenge owing to poor analyte stability in biological matrices. The primary goal …

Rapid analysis of anabolic steroid metabolites in urine by combining field asymmetric waveform ion mobility spectrometry with liquid chromatography and mass …

KL Arthur, MA Turner, AD Brailsford… - Analytical …, 2017 - ACS Publications
The combination of field asymmetric waveform ion mobility spectrometry with liquid
chromatography–mass spectrometry (LC-FAIMS-MS) has been developed for the analysis of …

Increasing peak capacity in nontargeted omics applications by combining full scan field asymmetric waveform ion mobility spectrometry with liquid chromatography …

KL Arthur, MA Turner, JC Reynolds… - Analytical …, 2017 - ACS Publications
Full scan field asymmetric waveform ion mobility spectrometry (FAIMS) combined with liquid
chromatography and mass spectrometry (LC-FAIMS-MS) is shown to enhance peak capacity …

Differential ion mobility separations in up to 100% helium using microchips

AA Shvartsburg, YM Ibrahim… - Journal of the American …, 2014 - ACS Publications
The performance of differential IMS (FAIMS) analyzers is much enhanced by gases
comprising He, especially He/N2 mixtures. However, electrical breakdown has limited the …

Combined hydrophilic interaction liquid chromatography-scanning field asymmetric waveform ion mobility spectrometry-time-of-flight mass spectrometry for untargeted …

KM Szykuła, J Meurs, MA Turner, CS Creaser… - Analytical and …, 2019 - Springer
Untargeted metabolite profiling of biological samples is a challenge for analytical science
due to the high degree of complexity of biofluids. Isobaric species may also not be resolved …

Direct analysis of oil additives by high-field asymmetric waveform ion mobility spectrometry-mass spectrometry combined with electrospray ionization and desorption …

C Da Costa, M Turner, JC Reynolds… - Analytical …, 2016 - ACS Publications
The analysis of corrosion inhibitors in the presence and absence of an oil matrix is reported
using electrospray ionization (ESI) and desorption electrospray ionization (DESI) …

FAIMS-MS-IR spectroscopy workflow: a multidimensional platform for the analysis of molecular isoforms

B Schindler, AD Depland, G Renois-Predelus… - International Journal for …, 2017 - Springer
An original workflow allowing inline FAIMS separation, electrospray ionization, mass
analysis and ion spectroscopy (IRMPD: InfraRed Multiple Photon Dissociation) is presented …

HRMS: Hardware and software

JF García-Reyes, D Moreno-González… - Applications in High …, 2017 - Elsevier
In this chapter, an overview of the more commonly used high-resolution mass spectrometry
(HRMS) instrumentation is provided, including the description of time-of-flight, Fourier …

Multidimensional separation of natural products using liquid chromatography coupled to Hadamard transform ion mobility mass spectrometry

W Liu, X Zhang, R Knochenmuss… - Journal of The …, 2016 - ACS Publications
A high performance liquid chromatograph (HPLC) was interfaced to an atmospheric drift
tube ion mobility time of flight mass spectrometry. The power of multidimensional separation …