Natural killer cells in cancer biology and therapy

SY Wu, T Fu, YZ Jiang, ZM Shao - Molecular cancer, 2020 - Springer
The tumor microenvironment is highly complex, and immune escape is currently considered
an important hallmark of cancer, largely contributing to tumor progression and metastasis …

Immune checkpoint molecules in natural killer cells as potential targets for cancer immunotherapy

Y Cao, X Wang, T Jin, Y Tian, C Dai… - Signal transduction and …, 2020 - nature.com
Recent studies have demonstrated the potential of natural killer (NK) cells in immunotherapy
to treat multiple types of cancer. NK cells are innate lymphoid cells that play essential roles …

Immune responses in bladder cancer-role of immune cell populations, prognostic factors and therapeutic implications

M Joseph, D Enting - Frontiers in oncology, 2019 - frontiersin.org
Immunosurveillance, which describes the immunologically mediated elimination of
transformed cells, has been widely accepted in the context of bladder cancer for many …

Effects of yoga in men with prostate cancer on quality of life and immune response: a pilot randomized controlled trial

D Kaushik, PK Shah, N Mukherjee, N Ji… - Prostate cancer and …, 2022 - nature.com
Background Diagnosis and treatment of prostate cancer is associated with anxiety, fear, and
depression in up to one-third of men. Yoga improves health-related quality of life (QoL) in …

CD200 ectodomain shedding into the tumor microenvironment leads to NK cell dysfunction and apoptosis

HJ Morgan, E Rees, S Lanfredini… - The Journal of …, 2022 - Am Soc Clin Investig
The basis of immune evasion, a hallmark of cancer, can differ even when cancers arise from
one cell type such as in the human skin keratinocyte carcinomas: basal and squamous cell …

Natural killer cell therapy: a new treatment paradigm for solid tumors

S Oh, JH Lee, KB Kwack, SW Choi - Cancers, 2019 - mdpi.com
In treatments of solid tumors, adoptive transfer of ex vivo expanded natural killer (NK) cells
has dawned as a new paradigm. Compared with cytotoxic T lymphocytes, NK cells take a …

miR-221-5p and miR-186-5p are the critical bladder cancer derived exosomal miRNAs in natural killer cell dysfunction

T Huyan, L Gao, N Gao, C Wang, W Guo… - International Journal of …, 2022 - mdpi.com
Bladder cancer (BC) is the tenth most commonly diagnosed cancer worldwide, and its
carcinogenesis mechanism has not been fully elucidated. BC is able to induce natural killer …

A TP53-associated immune prognostic signature for the prediction of overall survival and therapeutic responses in muscle-invasive bladder cancer

X Wu, D Lv, C Cai, Z Zhao, M Wang, W Chen… - Frontiers in …, 2020 - frontiersin.org
Background TP53 gene mutation is one of the most common mutations in human bladder
cancer (BC) and has been implicated in the progression and prognosis of BC. Methods RNA …

Metabolic adaptation of NK cell activity and behavior in tumors: challenges and therapeutic opportunities

S Borde, S Matosevic - Trends in Pharmacological Sciences, 2023 - cell.com
The adaptation of natural killer (NK) cells to conditions in the microenvironment of tumors is
deeply affected by their metabolic activity, itself a result of nutrient availability and the …

Intratumoral NKp46+ natural killer cells are spatially distanced from T and MHC-I+ cells with prognostic implications in soft tissue sarcoma

SM Cruz, CJ Sholevar, SJ Judge, MA Darrow… - Frontiers in …, 2023 - frontiersin.org
Introduction Soft tissue sarcomas (STS) are rare, heterogenous malignancies with an unmet
need for novel immunotherapies. Tumor infiltrating lymphocytes (TILs) have been linked with …