Efficacy and safety of dual combination therapy of blood pressure-lowering drugs as initial treatment for hypertension: a systematic review and meta-analysis of …

A Salam, R Kanukula, E Atkins, X Wang… - Journal of …, 2019 - journals.lww.com
Objective: To assess the efficacy and tolerability of dual combination of blood pressure (BP)-
lowering drugs as initial treatment for hypertension. Methods: MEDLINE, Embase …

Two‐drug fixed‐dose combinations of blood pressure‐lowering drugs as WHO essential medicines: an overview of efficacy, safety, and cost

A Salam, MD Huffman, R Kanukula… - The Journal of …, 2020 - Wiley Online Library
Cardiovascular diseases (CVD) are the world's leading cause of death. High blood pressure
(BP) is the leading global risk factor for all‐cause preventable morbidity and mortality …

Fixed low-dose triple combination antihypertensive medication vs usual care for blood pressure control in patients with mild to moderate hypertension in Sri Lanka: a …

R Webster, A Salam, HA De Silva, V Selak, S Stepien… - Jama, 2018 - jamanetwork.com
Importance Poorly controlled hypertension is a leading global public health problem
requiring new treatment strategies. Objective To assess whether a low-dose triple …

Combination therapy in hypertension

AH Gradman, JN Basile, BL Carter, GL Bakris… - Journal of the American …, 2010 - Elsevier
The goal of antihypertensive therapy is to abolish the risks associated with blood pressure
(BP) elevation without adversely affecting quality of life. Drug selection is based on efficacy …

Combining medications to enhance depression outcomes (CO-MED): acute and long-term outcomes of a single-blind randomized study

AJ Rush, MH Trivedi, JW Stewart… - American Journal of …, 2011 - Am Psychiatric Assoc
Objective: Two antidepressant medication combinations were compared with selective
serotonin reuptake inhibitor monotherapy to determine whether either combination …

Efficacy and safety of a novel low-dose triple single-pill combination of telmisartan, amlodipine and indapamide, compared with dual combinations for treatment of …

A Rodgers, A Salam, AE Schutte, WC Cushman… - The Lancet, 2024 - thelancet.com
Summary Background Single-pill combinations (SPCs) of three low-dose antihypertensive
drugs can improve hypertension control but are not widely available. A key issue for any …

Combination therapy in hypertension

AH Gradman, JN Basile, BL Carter… - The Journal of …, 2011 - Wiley Online Library
Editor's Note: The American Society of Hypertension is publishing a series of Position
Papers in their official journals throughout the 2008–2011 years. The following Position …

Combination therapy is superior to sequential monotherapy for the initial treatment of hypertension: a double‐blind randomized controlled trial

TM MacDonald, B Williams, DJ Webb… - Journal of the …, 2017 - Am Heart Assoc
Background Guidelines for hypertension vary in their preference for initial combination
therapy or initial monotherapy, stratified by patient profile; therefore, we compared the …

Angiotensin-converting enzyme inhibitor associated cough: deceptive information from the Physicians' Desk Reference

S Bangalore, S Kumar, FH Messerli - The American journal of medicine, 2010 - Elsevier
BACKGROUND: Dry cough is a common, annoying adverse effect of all angiotensin-
converting enzyme (ACE) inhibitors. The present study was designed to compare the rate of …

Comparative effectiveness of moderate-intensity statin with ezetimibe therapy versus high-intensity statin monotherapy in patients with acute coronary syndrome: a …

JY Jang, S Kim, J Cho, S Chun, SC You, JS Kim - Scientific Reports, 2024 - nature.com
The long-term outcome of first-line moderate-intensity statin with ezetimibe combination
therapy for secondary prevention after percutaneous coronary intervention in patients with …