Purpose Age-related macular degeneration (AMD) is a leading cause of blindness,
particularly in higher-income countries. Although dry AMD accounts for 85% to 90% of AMD …

The three interacting components of the outer blood-retinal barrier are the retinal pigment
epithelium (RPE), choriocapillaris, and Bruch's membrane, the extracellular matrix that lies …

Purpose To analyze the prevalence, incidence, and clinical characteristics of eyes with
geographic atrophy (GA) in age-related macular degeneration (AMD), including clinical and …

Highlights•Aging is the major risk factor for AMD.•The macula contains more than 60 kinds of
cells that may age at different rates.•The retinal aging in AMD is determined by its interplay …

Age-related macular degeneration (AMD) is a devastating disease-causing vision loss in
millions of people around the world. In advanced stages of disease, death of photoreceptor …

Over the past decade, a surge of evidence has documented various pathological processes
in the retina of patients suffering from mild cognitive impairment, Alzheimer's disease (AD) …

Introduction The specific impact from the patient's perspective of geographic atrophy (GA),
an advanced form of age-related macular degeneration (AMD), is not well understood …

Age-related macular degeneration (AMD) is a degenerative disease of the human retina
affecting individuals over the age of 55 years. This heterogeneous condition arises from a …

Purpose To investigate differences in the development of macular atrophy (MA) over 24
months between treat-and-extend (T&E) ranibizumab and aflibercept in patients with …

Lipids play essential roles in maintaining cell structure and function by modulating
membrane fluidity and cell signaling. The fatty acid elongase-4 (ELOVL4) protein, expressed …