Recent antimalarial drug discovery has been a race to produce new medicines that
overcome emerging drug resistance, whilst considering safety and improving dosing …

The Apicomplexa phylum comprises thousands of distinct intracellular parasite species,
including coccidians, haemosporidians, piroplasms, and cryptosporidia. These parasites are …

Identifying how small molecules act to kill malaria parasites can lead to new “chemically
validated” targets. By pressuring Plasmodium falciparum asexual blood stage parasites with …

The amide is one of the most prevalent functional groups throughout natural and engineered
chemical space. Among various methods of constructing amide bonds, lactone aminolysis …

Transgenic luciferase-expressing Plasmodium falciparum parasites have been widely used
for the evaluation of anti-malarial compounds. Here, to screen for anti-malarial drugs …

Novel antimalarial compounds targeting both the pathogenic and transmissible stages of the
human malaria parasite, Plasmodium falciparum, would greatly benefit malaria elimination …

Introduction Low metabolic clearance is usually a highly desirable property of drug
candidates in order to reduce dose and dosing frequency. However, measurement of low …

Highlights•Many antimalarial drug targets discovered using reverse chemical genetic
methods are druggable in other species.•tRNA synthetases seem to be one of the most …

Malaria is a parasitic disease that remains a global health issue, responsible for a significant
death and morbidity toll. Various factors have impacted the use and delayed the …

Ferroptosis is an iron-dependent form of regulated cell death characterized by glutathione
(GSH) depletion, glutathione peroxidase 4 (GPX4) inactivation, and the build-up of lipotoxic …