The inositol 1, 4, 5-trisphosphate (InsP3) receptors (InsP3Rs) are a family of Ca2+ release
channels localized predominately in the endoplasmic reticulum of all cell types. They …

The inositol (1, 4, 5)-trisphosphate receptors (InsP3R) are the intracellular calcium (Ca2+)
release channels that play a key role in Ca2+ signaling in cells. Three InsP3R isoforms …

Dendrite pruning is critical for sculpting the final connectivity of neural circuits as it removes
inappropriate projections, yet how neurons can selectively eliminate unnecessary dendritic …

Inositol 1, 4, 5-trisphosphate receptors (IP3Rs) initiate a diverse array of physiological
responses by carefully orchestrating intracellular calcium (Ca2+) signals in response to …

Neuronal Ca2+ signals can affect excitability and neural circuit formation. Ca2+ signals are
modified by Ca2+ flux from intracellular stores as well as the extracellular milieu. However …

Mechanisms by which G-protein-coupled odorant receptors transduce information in insects
still need elucidation. We show that mutations in the Drosophila gene for Gqα (dgq) …

Mutations in> 50 genes, including spastin and atlastin, lead to hereditary spastic paraplegia
(HSP). We previously demonstrated that reduction of spastin leads to a deficit in axon …

Cytoplasmic accumulation of TDP-43 in motor neurons is the most prominent pathological
feature in amyotrophic lateral sclerosis (ALS). A feedback cycle between nucleocytoplasmic …

Obesity is a complex metabolic disorder that often manifests with a strong genetic
component in humans. However, the genetic basis for obesity and the accompanying …

Calcium signalling is a highly versatile cellular communication system that modulates basic
functions such as cell contractility, essential steps of animal development such as …