Leukocyte extravasation is one of the essential and first steps during the initiation of
inflammation. Therefore, a better understanding of the key molecules that regulate this …

Following the seminal discovery of insulin a century ago, treatment of individuals with type 1
diabetes (T1D) has been largely restricted to efforts to monitor and treat metabolic glucose …

Tissue-specific autoimmune diseases are driven by activation of diverse immune cells in the
target organs. However, the molecular signatures of immune cell populations over time in an …

The microbiome is a complex community of Bacteria, Archaea, Eukarya, and viruses that
infect humans and live in our tissues. It contributes the majority of genetic information to our …

Type 1 diabetes is an autoimmune disease with onset from early childhood. The insulin-
producing pancreatic beta cells are destroyed by CD8+ cytotoxic T cells. The disease is …

Background T1D is an autoimmune disease in which pancreatic islets of Langerhans are
infiltrated by immune cells resulting in the specific destruction of insulin-producing islet beta …

Type-1 diabetes in the nonobese diabetic (NOD) mouse starts with an insulitis stage,
wherein a mixed population of leukocytes invades the pancreas, followed by overt diabetes …

Our ability to successfully intervene in disease processes is dependent on definitive
diagnosis. In the case of autoimmune disease, this is particularly challenging because …

The autoimmune destruction of the pancreatic islet β cells is due to a targeted lymphocyte
attack. Different T cell subsets communicate with each other and with the insulin-producing β …

Abstract Type 1 diabetes (T1D) develops due to autoimmune targeting of the pancreatic islet
β-cells. Clinical symptoms arise from reduced insulin in circulation. The molecular events …