The p38 signal transduction pathway activation and function
The p38 signalling transduction pathway, a Mitogen-activated protein (MAP) kinase
pathway, plays an essential role in regulating many cellular processes including …
pathway, plays an essential role in regulating many cellular processes including …
Hydrogen sulfide‐induced apoptosis of human aorta smooth muscle cells via the activation of mitogen‐activated protein kinases and caspase‐3
The endogenous production of hydrogen sulfide (H2S) and its physiological functions,
including membrane hyperpolarization and smooth muscle cell relaxation, position this gas …
including membrane hyperpolarization and smooth muscle cell relaxation, position this gas …
Circular RNA MAPK4 (circ-MAPK4) inhibits cell apoptosis via MAPK signaling pathway by sponging miR-125a-3p in gliomas
J He, Z Huang, M He, J Liao, Q Zhang, S Wang, L Xie… - Molecular cancer, 2020 - Springer
Background Recent evidences have shown that circular RNAs (circRNAs) are frequently
dysregulated and play paramount roles in various cancers. circRNAs are abundant in …
dysregulated and play paramount roles in various cancers. circRNAs are abundant in …
The pyridinyl imidazole inhibitor SB203580 blocks phosphoinositide-dependent protein kinase activity, protein kinase B phosphorylation, and retinoblastoma …
FV Lali, AE Hunt, SJ Turner, BMJ Foxwell - Journal of Biological Chemistry, 2000 - ASBMB
Pyridinyl imidazole inhibitors, particularly SB203580, have been widely used to elucidate
the roles of p38 mitogen-activated protein (MAP) kinase (p38/HOG/SAPKII) in a wide array of …
the roles of p38 mitogen-activated protein (MAP) kinase (p38/HOG/SAPKII) in a wide array of …
Stress-activated protein kinase/JNK activation and apoptotic induction by the macrophage P2X7 nucleotide receptor
BD Humphreys, J Rice, SB Kertesy… - Journal of Biological …, 2000 - ASBMB
In human and rodent macrophages, activation of the P2X7 nucleotide receptor stimulates
interleukin-1β processing and release, apoptosis, and killing of intracellular Mycobacterium …
interleukin-1β processing and release, apoptosis, and killing of intracellular Mycobacterium …
Bone morphogenetic protein-2 promotes osteoblast apoptosis through a Smad-independent, protein kinase C-dependent signaling pathway
E Haÿ, J Lemonnier, O Fromigué, PJ Marie - Journal of Biological Chemistry, 2001 - ASBMB
Bone morphogenetic protein-2 (BMP-2), a member of the transforming growth factor-β (TGF-
β) family, regulates osteoblast differentiation and bone formation. Here we show a novel …
β) family, regulates osteoblast differentiation and bone formation. Here we show a novel …
Cytotoxic activity of hydrolyzable tannins against human oral tumor cell lines—a possible mechanism
H Sakagami, Y Jiang, K Kusama, T Atsumi, T Ueha… - Phytomedicine, 2000 - Elsevier
Hydrolyzable tannins showed higher cytotoxic activity against human oral squamous cell
carcinoma and salivary gland tumor cell lines than against normal human gingival …
carcinoma and salivary gland tumor cell lines than against normal human gingival …
ATP treatment of human monocytes promotes caspase-1 maturation and externalization
RE Laliberte, J Eggler, CA Gabel - Journal of Biological Chemistry, 1999 - ASBMB
Mechanisms that regulate conversion of prointerleukin-1β (pro-IL-1β) to its mature form by
the cysteine protease caspase-1 are not well understood. In this study, we demonstrate that …
the cysteine protease caspase-1 are not well understood. In this study, we demonstrate that …
The lipid peroxidation product 4‐hydroxy‐2, 3‐nonenal increases AP‐1‐binding activity through caspase activation in neurons
The transcription factor activator protein‐1 (AP‐1) is activated in response to physiological
activity in neuronal circuits and in response to neuronal injury associated with various acute …
activity in neuronal circuits and in response to neuronal injury associated with various acute …
Ras-MAP kinase signaling pathways and control of cell proliferation: relevance to cancer therapy
P Shapiro - Critical reviews in clinical laboratory sciences, 2002 - Taylor & Francis
The mitogen-activated protein (MAP) kinase pathways represent several families of signal
transduction cascades that mediate information provided by extracellular stimuli. MAP …
transduction cascades that mediate information provided by extracellular stimuli. MAP …