Aldehyde dehydrogenase (ALDH) is a superfamily of enzymes that detoxify a variety of
endogenous and exogenous aldehydes and are required for the biosynthesis of retinoic …

The human genome contains 19 putatively functional aldehyde dehydrogenase (ALDH)
genes, which encode enzymes critical for detoxification of endogenous and exogenous …

Glioblastoma (GBM) is the highest-grade form of glioma, as well as one of the most
aggressive types of cancer, exhibiting rapid cellular growth and highly invasive behavior …

Chemoresistant metastatic relapse of minimal residual disease plays a significant role for
poor prognosis of cancer. Growing evidence supports a critical role of cancer stem cell …

Cancer stem-like cells (CSCs), a subpopulation of cancer cells, possess remarkable
capability in proliferation, self-renewal, and differentiation. Their presence is recognized as a …

The identification of neurological symptoms caused by vitamin A deficiency pointed to a
critical, early developmental role of vitamin A and its metabolite, retinoic acid (RA). The …

Retinoids regulate a wide spectrum of cellular functions from the embryo throughout
adulthood, including cell differentiation, metabolic regulation, and inflammation. These traits …

Resistance to current chemotherapeutic or radiation-based cancer treatment strategies is a
serious concern. Cancer stem cells (CSCs) are typically able to evade treatment and …

Globally, prostate cancer (PCa) is regarded as a challenging health issue, and the number
of PCa patients continues to rise despite the availability of effective treatments in recent …

Rationale: Inducing cancer differentiation is a promising approach to treat cancer. Here, we
identified chlorogenic acid (CA), a potential differentiation inducer, for cancer therapy, and …