Endometriosis affects approximately 190 million women and people assigned female at birth
worldwide. It is a chronic, inflammatory, gynecologic disease marked by the presence of …

Genes play a strong role in Alzheimer's disease (AD), with late-onset AD showing heritability
of 58–79% and early-onset AD showing over 90%. Genetic association provides a robust …

Endometriosis is a common condition associated with debilitating pelvic pain and infertility.
A genome-wide association study meta-analysis, including 60,674 cases and 701,926 …

Disorders of the brain can exhibit considerable epidemiological comorbidity and often share
symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing …

INTRODUCTION Brain disorders may exhibit shared symptoms and substantial
epidemiological comorbidity, inciting debate about their etiologic overlap. However, detailed …

Abstract Knowledge of genetics and its implications for human health is rapidly evolving in
accordance with recent events, such as discoveries of large numbers of disease …

Abstract Narrow-sense heritability (h 2) is an important genetic parameter that quantifies the
proportion of phenotypic variance in a trait attributable to the additive genetic variation …

Genetic association studies have identified 44 common genome-wide significant risk loci for
late-onset Alzheimer's disease (LOAD). However, LOAD genetic architecture and prediction …

Most psychiatric disorders are moderately to highly heritable. The degree to which genetic
variation is unique to individual disorders or shared across disorders is unclear. To examine …

Background Despite evidence from twin and family studies for an important contribution of
genetic factors to both childhood and adult onset psychiatric disorders, identifying robustly …