Sigma (σ) receptors are a class of unique proteins with two subtypes: the sigma-1 (σ1)
receptor which is situated at the mitochondria-associated endoplasmic reticulum (ER) …

Radiopharmaceuticals involve the local delivery of radionuclides to targeted lesions for the
diagnosis and treatment of multiple diseases. Radiopharmaceutical therapy, which directly …

Novel ligands with the 6, 7-dimethoxy-1, 2, 3, 4-tetrahydroisoquinoline or 5, 6-
dimethoxyisoindoline pharmacophore were designed and synthesized for evaluation of their …

Novel sigma-2 (σ2) receptor ligands with benzimidazolone and 5, 6-dimethoxyisoindoline as
pharmacophores were designed and synthesized. Compound 4 exhibited low nanomolar …

The overexpression of σ receptors (σRs) in various types of tumors has prompted a deep
investigation of their role in cancer pathophysiology. Consequently, σR ligands have been …

As sigma receptors are highly expressed on various cancer cells, radiolabeled sigma
receptor ligands have been developed as imaging and therapeutic probes for cancer …

Adolf von Baeyer, 1866'da indigonun parçalanma ürünü olan oksindol'ü indirgeyerek indol
bileşiğini keşfetmiş ve 1869'da bir formül önermiştir. İndol, C8H7N formülüne sahiptir …