Exosomes offer distinct advantages that uniquely position them as highly effective drug
carriers. Comprised of cellular membranes with multiple adhesive proteins on their surface …

Extracellular vesicles (EVs) are a heterogeneous population of secreted membrane
vesicles, with distinct biogenesis routes, biophysical properties and different functions both …

Central nervous system (CNS) injuries, such as stroke, traumatic brain injury (TBI) and
spinal cord injury (SCI), are important causes of death and long-term disability worldwide …

Cell-based therapy, eg, multipotent mesenchymal stromal cell (MSC) treatment, shows
promise for the treatment of various diseases. The strong paracrine capacity of these cells …

Stroke is a life‐threatening disease that accounts for a considerable burden of mortality in
both developing and developed world. Identification of specific biomarkers for stroke and its …

Drug nanoformulations hold remarkable promise for the efficient delivery of therapeutics to a
disease site. Unfortunately, artificial nanocarriers, mostly liposomes and polymeric …

Stem cell-based treatments have been suggested as promising candidates for stroke.
Recently, mesenchymal stem cells (MSCs) have been reported as potential therapeutics for …

Ischemia induces extensive temporal changes in cerebral transcriptome that influences the
neurologic outcome after stroke. In addition to protein-coding RNAs, many classes of …

Ischemic stroke, which is caused by a clot that blocks blood flow to the brain, can be
severely disabling and sometimes fatal. We previously showed that transient focal ischemia …

Given the essential role of the blood-brain barrier (BBB) in the central nervous system
(CNS), cumulative investigations have been performed to elucidate how modulation of BBB …