Latest developments in molecular tracers for fluorescence image-guided cancer surgery

S Hernot, L van Manen, P Debie, JSD Mieog… - The lancet …, 2019 - thelancet.com
Real-time intraoperative guidance is essential during oncological surgery for complete and
safe tumour resection. Fluorescence imaging in the near-infrared spectrum has shown …

Intraoperative imaging in pathology-assisted surgery

FJ Voskuil, J Vonk, B van der Vegt, S Kruijff… - Nature biomedical …, 2022 - nature.com
The pathological assessment of surgical specimens during surgery can reduce the
incidence of positive resection margins, which otherwise can result in additional surgeries or …

A proposal to redefine close surgical margins in squamous cell carcinoma of the oral tongue

DK Zanoni, JC Migliacci, B Xu, N Katabi… - … –Head & Neck …, 2017 - jamanetwork.com
Importance Resection of the primary tumor with negative margins is the gold standard
treatment for squamous cell carcinoma of the oral tongue (SCCOT). A microscopically …

[HTML][HTML] Fluorescence-guided imaging for resection margin evaluation in head and neck cancer patients using cetuximab-800CW: a quantitative dose-escalation study

FJ Voskuil, SJ de Jongh, WTR Hooghiemstra… - Theranostics, 2020 - ncbi.nlm.nih.gov
Tumor-positive resection margins are present in up to 23% of head and neck cancer (HNC)
surgeries, as intraoperative techniques for real-time evaluation of the resection margins are …

Recent advances of aggregation-induced emission materials for fluorescence image-guided surgery

W He, Z Zhang, Y Luo, RTK Kwok, Z Zhao, BZ Tang - Biomaterials, 2022 - Elsevier
Real-time intraoperative guidance is essential during various surgical treatment of many
diseases. Aggregation-induced emission (AIE) materials have shown great potential for …

Sensitivity and specificity of cetuximab-IRDye800CW to identify regional metastatic disease in head and neck cancer

EL Rosenthal, LS Moore, K Tipirneni, E de Boer… - Clinical Cancer …, 2017 - AACR
Purpose: Comprehensive cervical lymphadenectomy can be associated with significant
morbidity and poor quality of life. This study evaluated the sensitivity and specificity of …

A meta-analysis of margin size and local recurrence in oral squamous cell carcinoma

CR Anderson, K Sisson, M Moncrieff - Oral oncology, 2015 - Elsevier
Objectives: Excision margins for oral squamous cell carcinoma (OSCC) are poorly
understood. Close (< 5 mm) and involved (< 1 mm) pathological margins are key indicators …

Definition of “close margin” in oral cancer surgery and association of margin distance with local recurrence rate

KK Tasche, MR Buchakjian, NA Pagedar… - … –Head & Neck …, 2017 - jamanetwork.com
Importance There is a lack of consistency in the literature regarding the definition of “close”
resection margins in the surgical treatment of oral cavity squamous cell carcinoma …

Time to recurrence and patient survival in recurrent oral squamous cell carcinoma

A Weckx, M Riekert, A Grandoch, V Schick, JE Zoeller… - Oral oncology, 2019 - Elsevier
Objectives Tumour relapse remains one of the major problems in managing oral squamous
cell carcinoma (OSCC) with mortality rates of up to 92%. Early recurrences have a worse …

Improving oral cavity cancer diagnosis and treatment with fluorescence molecular imaging

J Vonk, JG de Wit, FJ Voskuil, MJH Witjes - Oral diseases, 2021 - Wiley Online Library
Early diagnosis and radical surgical excision of oral squamous cell carcinomas are essential
for achieving optimal treatment outcomes. To date, diagnostic tools that rely on anatomical …