Glycosylation markers in cancer

A Silsirivanit - Advances in clinical chemistry, 2019 - Elsevier
Alteration of glycosylation, a hallmark of cancer, results in the production of tumor-
associated glycans or glycoproteins. These molecules are subsequently secreted or …

Functional roles of N‐glycans in cell signaling and cell adhesion in cancer

YY Zhao, M Takahashi, JG Gu, E Miyoshi… - Cancer …, 2008 - Wiley Online Library
Glycosylation is one of the most common post‐translational modification reactions and
nearly half of all known proteins in eukaryotes are glycosylated. In fact, changes in …

Core fucosylation regulates epidermal growth factor receptor-mediated intracellular signaling

X Wang, J Gu, H Ihara, E Miyoshi, K Honke… - Journal of Biological …, 2006 - ASBMB
α1, 6-Fucosyltransferase (Fut8) catalyzes the transfer of a fucose residue to N-linked
oligosaccharides on glycoproteins via an α1, 6-linkage to form core fucosylation in …

Ligand anchored poly (propyleneimine) dendrimers for brain targeting: Comparative in vitro and in vivo assessment

HK Patel, V Gajbhiye, P Kesharwani, NK Jain - Journal of colloid and …, 2016 - Elsevier
The present investigation was aimed at developing various ligands-anchored dendrimers
and comparing their brain targeting potential at one platform. Sialic acid (S), glucosamine …

The Asn-420-linked sugar chain in human epidermal growth factor receptor suppresses ligand-independent spontaneous oligomerization: possible role of a specific …

T Tsuda, Y Ikeda, N Taniguchi - Journal of Biological Chemistry, 2000 - ASBMB
To elucidate a role (s) of Asn-linked sugar chain (s) in the function of epidermal growth factor
receptor (EGFR), a series of the EGFR mutants were prepared in which potential …

European Viscum album: a potent phytotherapeutic agent with multifarious phytochemicals, pharmacological properties and clinical evidence

BN Singh, C Saha, D Galun, DK Upreti, J Bayry… - RSC …, 2016 - pubs.rsc.org
Viscum album L. or European mistletoe (Loranthaceae), a semi-parasitic shrub, has been
used as a traditional medicine in Europe for centuries to treat various diseases like cancer …

Vicia faba agglutinin, the lectin present in broad beans, stimulates differentiation of undifferentiated colon cancer cells

M Jordinson, I El-Hariry, D Calnan, J Calam… - Gut, 1999 - gut.bmj.com
BACKGROUND Dietary lectins can alter the proliferation of colonic cells. Differentiation is
regulated by adhesion molecules which, being glycosylated, are targets for lectin binding …

Phenotype changes of Fut8 knockout mouse: core fucosylation is crucial for the function of growth factor receptor (s)

X Wang, J Gu, E Miyoshi, K Honke, N Taniguchi - Methods in enzymology, 2006 - Elsevier
Abstract α1, 6‐Fucosyltransferase (Fut8) catalyzes the transfer of a fucose residue to N‐
linked oligosaccharides on glycoproteins by means of an α1, 6‐linkage to form core …

Agrarian diet and diseases of affluence–Do evolutionary novel dietary lectins cause leptin resistance?

T Jönsson, S Olsson, B Ahrén, TC Bøg-Hansen… - BMC Endocrine …, 2005 - Springer
Background The global pattern of varying prevalence of diseases of affluence, such as
obesity, cardiovascular disease and diabetes, suggests that some environmental factor …

Role of N-glycans in growth factor signaling

M Takahashi, T Tsuda, Y Ikeda, K Honke… - Glycoconjugate …, 2003 - Springer
Secreted proteins and membrane proteins are frequently post-translationally modified by
oligosaccharides. Therefore, many glycoproteins are involved in signal transduction. One …