Microtubules are polarized cytoskeletal filaments that serve as tracks for intracellular
transport and form a scaffold that positions organelles and other cellular components and …

Neurons depend on the highly dynamic microtubule (MT) cytoskeleton for many different
processes during early embryonic development including cell division and migration …

INTRODUCTION The microtubule cytoskeleton is continuously sculpted by polymerization,
depolymerization, cross-linking, and microtubule severing. Microtubule severing generates …

Tubulin posttranslational modifications have been predicted to control cytoskeletal functions
by coordinating the molecular interactions between microtubules and their associating …

Microtubule-severing enzymes generate internal breaks in microtubules. They are
conserved in eukaryotes from ciliates to mammals, and their function is important in diverse …

Tau is an intrinsically disordered protein, which diffuses on microtubules. In
neurodegenerative diseases, collectively termed tauopathies, malfunction of tau and its …

Local translation allows for a spatial control of gene expression. Here, we use high-
throughput smFISH to screen centrosomal protein-coding genes, and we describe 8 human …

Recurrent and hormone-refractory prostate cancer (PCA) exhibits aggressive behaviors
while current therapeutic approaches show little effect of prolonging the survival of patients …

Abstract γ-Tubulin ring complex (γ-TuRC) is the major microtubule-nucleating factor. After
nucleation, microtubules can be released from γ-TuRC and stabilized by other proteins …

Microtubule-severing enzymes–katanin, spastin, fidgetin–are related AAA-ATPases that cut
microtubules into shorter filaments. These proteins, also called severases, are involved in a …