A critical element of successful sexual reproduction is the generation of sexually dimorphic
adult reproductive organs, the testis and ovary, which produce functional gametes …

Our understanding of avian sex determination and gonadal development is derived primarily
from the studies in the chicken. Analysis of gynandromorphic chickens and experimental …

Following on from the First Report on Chicken Genes and Chromosomes [Schmid et al.,
2000] and the Second Report in 2005 [Schmid et al., 2005], we are pleased to publish this …

Although vertebrates display a superficial bilateral symmetry, most internal organs develop
and locate with a consistent left: right asymmetry. There is still considerable debate as to …

Multicomponent molecular modifications such as DNA methylation may offer sensitive and
specific cervical intraepithelial neoplasia and cervical cancer biomarkers. In this study, we …

Differentiation of the bipotential gonadal primordium into ovaries and testes is a common
process among vertebrate species. While vertebrate ovaries eventually share the same …

In chickens, the embryonic ovary differentiates into two distinct domains before meiosis: a
steroidogenic core (the female medulla), overlain by the germ cell niche (the cortex). The …

Background Paired-like homeodomain 2 (PITX2) is a bicoid homeodomain transcription
factor which plays an essential role in maintaining embryonic left-right asymmetry during …

Pitx2 is a conserved homeodomain transcription factor that has multiple functions during
embryonic development. Mutations in human PITX2 cause autosomal dominant Axenfeld …

The primary role of Anti-Müllerian hormone (AMH) during mammalian development is the
regression of Müllerian ducts in males. This highly conserved function is retained in birds …