Immunotherapy and liver transplantation: A narrative review of basic and clinical data
CH Wassmer, S El Hajji, X Papazarkadas… - Cancers, 2023 - mdpi.com
Simple Summary Hepatocellular carcinoma (HCC) represents one of the main indications
for liver transplantation. Over recent years, immune checkpoint inhibitor (ICI) therapy has …
for liver transplantation. Over recent years, immune checkpoint inhibitor (ICI) therapy has …
Epigenetics and CD8+ T cell memory*
G Montacchiesi, L Pace - Immunological Reviews, 2022 - Wiley Online Library
Following antigen recognition, CD8+ T lymphocytes can follow different patterns of
differentiation, with the generation of different subsets characterized by distinct phenotypes …
differentiation, with the generation of different subsets characterized by distinct phenotypes …
mTOR regulates T cell exhaustion and PD-1–targeted immunotherapy response during chronic viral infection
S Ando, CM Perkins, Y Sajiki… - The Journal of …, 2023 - Am Soc Clin Investig
T cell exhaustion is a state of T cell dysfunction associated with expression of programmed
death 1 (PD-1). Exhausted CD8+ T cells are maintained by self-renewing stem-like T cells …
death 1 (PD-1). Exhausted CD8+ T cells are maintained by self-renewing stem-like T cells …
Tonic-signaling chimeric antigen receptors drive human regulatory T cell exhaustion
Regulatory T cell (Treg) therapy is a promising approach to improve outcomes in
transplantation and autoimmunity. In conventional T cell therapy, chronic stimulation can …
transplantation and autoimmunity. In conventional T cell therapy, chronic stimulation can …
Resident memory T cells form during persistent antigen exposure leading to allograft rejection
Tissue-resident memory T cells (TRM) contained at sites of previous infection provide local
protection against reinfection. Whether they form and function in organ transplants where …
protection against reinfection. Whether they form and function in organ transplants where …
CD4+ T cell immunity is dependent on an intrinsic stem-like program
CD4+ T cells are central to various immune responses, but the molecular programs that
drive and maintain CD4+ T cell immunity are not entirely clear. Here we identify a stem-like …
drive and maintain CD4+ T cell immunity are not entirely clear. Here we identify a stem-like …
Schrödinger's T cells: molecular insights into stemness and exhaustion
T cell stemness and exhaustion coexist as two key contrasting phenomena during chronic
antigen stimulation, such as infection, transplant, cancer, and autoimmunity. T cell …
antigen stimulation, such as infection, transplant, cancer, and autoimmunity. T cell …
Exosomes derived from LPS-preconditioned bone marrow-derived MSC modulate macrophage plasticity to promote allograft survival via the NF-κB/NLRP3 signaling …
PY Zhang, P Wu, UZ Khan, Z Zhou, X Sui, C Li… - Journal of …, 2023 - Springer
Objectives This study investigated whether exosomes from LPS pretreated bone marrow
mesenchymal stem cells (LPS pre-MSCs) could prolong skin graft survival. Methods The …
mesenchymal stem cells (LPS pre-MSCs) could prolong skin graft survival. Methods The …
Heterogeneity in allospecific T cell function in transplant-tolerant hosts determines susceptibility to rejection following infection
CM McIntosh, JB Allocco, P Wang… - The Journal of …, 2023 - Am Soc Clin Investig
Even when successfully induced, immunological tolerance to solid organs remains
vulnerable to inflammatory insults, which can trigger rejection. In a mouse model of cardiac …
vulnerable to inflammatory insults, which can trigger rejection. In a mouse model of cardiac …
T-cell exhaustion in organ transplantation
Exhaustion of T cells occurs in response to long-term exposure to self and foreign antigens.
It limits T cell capacity to proliferate and produce cytokines, leading to an impaired ability to …
It limits T cell capacity to proliferate and produce cytokines, leading to an impaired ability to …