Human neuropeptide Y (hNPY) is one of the most widely expressed neurotransmitters in the
human central and peripheral nervous systems. It consists of 36 highly conserved amino …

The neuropeptide Y (NPY) system–comprising of neuropeptide Y, peptide YY, pancreatic
polypeptide and the corresponding Y receptors through which they act (Y1, Y2, Y4, Y5 and …

The broad clinical spectrum of neuroblastoma ranges from spontaneous regression to rapid
progression despite intensive multimodal therapy. This diversity is not fully explained by …

Adverse prognosis in Ewing sarcoma (ES) is associated with the presence of metastases,
particularly in bone, tumor hypoxia and chromosomal instability (CIN). Yet, a mechanistic …

Neuropeptide Y (NPY) is a neuropeptide abundantly expressed in the mammalian central
and peripheral nervous system. NPY is a pleiotropic molecule, which influences cell …

Receptors for some regulatory peptides are highly expressed in tumors. Selective
radiolabeled peptides can bind with high affinity and specificity to these receptors and …

Emerging evidence suggests that nerves within the tumor microenvironment play a crucial
role in regulating angiogenesis. Neurotransmitters and neuropeptides released by nerves …

Currently available data on the involvement of neuropeptide Y (NPY), peptide YY (PYY), and
pancreatic polypeptide (PP) and their receptors (YRs) in cancer are updated. The structure …

Abstract NPY, PYY and PP constitute the so‐called NPY hormone family, which exert its
biological functions in humans through YRs (Y1, Y2, Y4 and Y5). Systematic modulation of …

Neuropeptide Y (NPY) and its receptors are expressed in various human tissues including
the brain where they regulate appetite and emotion. Upon NPY stimulation, the …