Over the past several decades, significant advances have been made in our understanding
of the basic stages and mechanisms of mammalian brain development. Studies elucidating …

During the development of the mammalian central nervous system, neural stem cells and
their derivative progenitor cells generate neurons by asymmetric and symmetric divisions …

Neurons of the mammalian CNS are thought to originate from progenitors dividing at the
apical surface of the neuroepithelium. Here we use mouse embryos expressing GFP from …

Heterotrimeric G-proteins are intracellular partners of G-protein-coupled receptors (GPCRs).
GPCRs act on inactive Gα· GDP/Gβγ heterotrimers to promote GDP release and GTP …

Apical plasma membrane constituents of mammalian neural stem/progenitor cells have
recently been implicated in maintaining their stem/progenitor cell state. Here, we report that …

During mammalian development, neuroepithelial cells function as mitotic progenitors, which
self-renew and generate neurons. Although spindle orientation is important for such …

In the mouse neocortex, neural progenitor cells generate both differentiating neurons and
daughter cells that maintain progenitor fate. Here, we show that the TRIM-NHL protein …

The development of cancer is a multistep process in which the DNA of a single cell
accumulates mutations in genes that control essential cellular processes. Loss of cell–cell …

At the onset of neurogenesis in the mammalian central nervous system, neuroepithelial cells
switch from symmetric, proliferative to asymmetric, neurogenic divisions. In analogy to the …

Asymmetric cell division of radial glial progenitors produces neurons while allowing self-
renewal; however, little is known about the mechanism that generates asymmetry in …